been away from the spaceport for a few days, not going back for a few more. scrambled thoughts are keeping me up, and somehow I ended up looking around for info on cyp450 and ayahuasca. it had something to do with a brew using white grapefruit juice (probably bogus; just some random thought), but I did stumble upon something interesting.
So,
harmaline is metabolized by cytochrome p450 2d6 (cyp2d6). somewhere else, harmine and thh were mentioned as being metabolized by cyp2d6 as well (too tired to find the link). Then, a search for safe cyp2d6 inhibitors yielded
this, which lists black pepper as a reasonably obtainable source.
I promptly came to search the nexus, and found the thread called
"Potentiation Blend?" and it's subsequent
successful report. not sure if there's a connection, but it sounds like such a good synergy I thought I'd repost.
Anyway, does anyone have any experience mixing black pepper and any of the harmalas or other maois? spice? if so, dosage/timeframe/effects? if someone can look in to how much P. nigrum material would need to be consumed to be an effective (noticeably) cyp2d6 inhibitor, that'd be a good start.
I'm anxious to try it out, but am not going to be able to do any experimenting for a little while - I'll post up if I'm the first to get around to trying it
EDIT: dug up
this old thread, doesn't seem to be many experience reports. I think a bit with some aya sounds promising though.