Here we demonstrate for the first time the immunomodulatory potential of NN-DMT and 5-MeO-DMT on human moDC functions via sigmar-1 that could be harnessed for the pharmacological treatment of autoimmune diseases and chronic inflammatory conditions of the CNS or peripheral tissues. Our findings also point out a new biological role for dimethyltryptamines, which may act as systemic endogenous regulators of inflammation and immune homeostasis through the sigma-1 receptor.
(From the paper titled " Psychedelic N,N-Dimethyltryptamine and 5-Methoxy-N,N-Dimethyltryptamine Modulate Innate and Adaptive Inflammatory Responses through the Sigma-1 Receptor of Human Monocyte-Derived Dendritic Cells" authors listed are: Attila Szabo , Attila Kovacs, Ede Frecska , Eva Rajnavolgyi)
For the full paper go to(
http://www.plosone.org/a...252Fjournal.pone.0106533 )
Fascinating stuff, I'm always amazed by the N,N-dimethyltryptamine molecule and all of its many potential functions.
-EG