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On the physiological role of DMT Options
 
efrecska
#1 Posted : 8/30/2014 1:59:10 AM
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Good quality Syrian rue (Peganum harmala) for an incredible price!
 
Infectedstyle
#2 Posted : 8/30/2014 12:54:48 PM
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thanks a lot!
 
nen888
#3 Posted : 8/30/2014 1:05:42 PM
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..yes that is interesting..and new..thanks efrecska
 
corpus callosum
#4 Posted : 8/30/2014 1:59:07 PM

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Very interesting; good find efrecska, and many thanks for posting Thumbs up .
I am paranoid of my brain. It thinks all the time, even when I'm asleep. My thoughts assail me. Murderous lechers they are. Thought is the assassin of thought. Like a man stabbing himself with one hand while the other hand tries to stop the blade. Like an explosion that destroys the detonator. I am paranoid of my brain. It makes me unsettled and ill at ease. Makes me chase my tail, freezes my eyes and shuts me down. Watches me. Eats my head. It destroys me.

 
Ufostrahlen
#5 Posted : 8/30/2014 2:27:44 PM

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corpus callosum wrote:
good find efrecska

He's probably the (co)-author of that paper. Thumbs up
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joedirt
#6 Posted : 8/30/2014 2:46:59 PM

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Ufostrahlen wrote:
corpus callosum wrote:
good find efrecska

He's probably the (co)-author of that paper. Thumbs up


You were close... looks like the third author! Pleased

Attila Szabo mail, Attila Kovacs, Ede Frecska , Eva Rajnavolgyi

If your religion, faith, devotion, or self proclaimed spirituality is not directly leading to an increase in kindness, empathy, compassion and tolerance for others then you have been misled.
 
efrecska
#7 Posted : 8/31/2014 2:44:25 AM
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This (the previous one) makes the picture more complete:
https://www.researchgate..._and_immunity?ev=prf_pub
FrEd

 
cave paintings
#8 Posted : 9/3/2014 7:44:26 PM

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Awesome! I think your work is really interesting. I've read through most of the paper you just posted and am working my way through your most recent work. I have been studying tumor-associated-macrophages (TAMS) and specifically their role in glioblastoma as promoters of angiogenesis. TAMS are often classified as a hyperpolarized M2 macrophage phenotype, with overactive immunosuppressive effects and uncontrolled angiogenesis. I have been curious as to what effect sigma receptor agonism might have on their phenotype, cytokine production, and migration. Considering the preferential, active uptake of DMT into the brain, it seems like a good candidate for affecting the brain's resident microglia. It is interesting to me to see the increase in NK cells following ayahuasca, and yet the reduction of pro-inflammatory cytokines also.
Forgive my ignorance in my speculations.. I am an undergrad, still learning my immunology. I wanted to ask your thoughts and speculations though on the subject.

Great work!
Living to Give
 
voyaj
#9 Posted : 9/5/2014 3:36:35 AM

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Yet another DMT related study & article about the possible benefits & implications from http://www.plosone.org/

It's pretty dense so I'll attach the article and for those impatient, here is the conclusion:

"We conclude that the function of dimethyltryptamines may
extend the central nervous system activity and may play a more
universal role in immune regulation. Here we demonstrate for the
first time that NN-DMT and 5-MeO-DMT have potent
immunomodulatory effects on the functional activities of human
dendritic cells operating through the sigma-1 receptor. We also
show that DMT-mediated sigmar-1 activation can interfere with
both innate and adaptive immune responses. On the one hand, it
strongly decreases the levels of pro-inflammatory cytokines and
chemokines such as IL-1b, IL-6, TNFa and IL8, while upregulates
the production of the anti-inflammatory cytokine IL-10. On the
other hand, NN-DMT and 5-MeO-DMT pre-treatment of
pathogen-activated moDCs abolishes their capacity to initiate
adaptive immune responses mediated by inflammatory Th1 and
Th17 cells. These findings greatly expand the biological role of
dimethyltryptamines, which may act not only as neuromodulators
or psychedelics, but also as important regulators of both innate
and adaptive immunity. Thus, the DMT-sigmar-1 axis emerges as
a promising candidate for novel pharmacotherapies of chronic
inflammatory and autoimmune diseases."

 
Endurance
#10 Posted : 9/10/2014 8:24:52 PM

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Thanks for sharing. Looking forward to hearing Dr. Frecska present at the Khanyisa Psychoactive Plant Conference later this year.
 
efrecska
#11 Posted : 9/15/2014 9:51:37 AM
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We will also present the results on the ICEERS AYA2014 meeting in Ibiza.
FrEd
 
efrecska
#12 Posted : 9/15/2014 9:56:34 AM
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[quote=cave paintings]: "Considering the preferential, active uptake of DMT into the brain, it seems like a good candidate for affecting the brain's resident microglia."
Yes! Good idea. The brain tissue cann't handle inflammation the same way peripheral tissues can. DMT can be a protective factor in keeeping inflammatory responses at bay.
FrEd
 
efrecska
#13 Posted : 9/15/2014 11:19:32 AM
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Beware of this hoax (a good one though):
http://worldnewsdailyrep...ere-is-life-after-death/
A cocktail containing DMT against brain hypoxia in voluntary clinical death (among flatliners)?!
Apparently, the pranksters have read our JNT paper.
FrEd
 
Ufostrahlen
#14 Posted : 9/16/2014 10:33:25 AM

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efrecska wrote:
Beware of this hoax (a good one though):
http://worldnewsdailyrep...ere-is-life-after-death/

Yeah, Technische Universität of Berlin doesn't have a clinical faculty or a Berthold Ackermann.
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