DMT-Nexus member
Posts: 110 Joined: 22-Oct-2011 Last visit: 24-Jan-2019 Location: colorado
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Hi yall, I am starting a new medication that was prescribed for psoriatic arthritis. It is called methotrexate, and has a lot of warnings about liver damage. I was told to drink very little, like 1 drink of alcohol per week and that is it. I haven't had the chance to try ayahuasca yet and was wondering if there is going to be problems with it. Thank you.
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DMT-Nexus member
 
Posts: 1952 Joined: 17-Apr-2010 Last visit: 05-May-2024 Location: somewhere west of here
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Methotrexate is undoubtedly a vicious medication which will require regular blood tests to monitor for toxicity in the liver and bone marrow; its primary effects are inhibitory on an enzyme called Dihydrofolate Reductase which has an important effect in cell replication and DNA synthesis.Its also used as an anti-cancer therapy in certain blood cancers and other ailments such as rheumatoid disease, sarcoid etc. Its liver toxicity is thought to result from this effect on DNA/RNA processing and results in fibrosis which in some ways resembles cirrhosis ie 'stiffens' the liver architecture. If used correctly adverse effects can be avoided (but not abolished); the problems often arise when the dosing frequency is increased in error from once a week to more often;its use more than once weekly in cancers accounts for the greater risks in this scenario. MAO inhibition is not problematic with methotrexate per se, but harmala alkaloids have on occasion raised liver enzymes which could complicate the interpretation of the liver function tests done routinely to monitor therapy.Also brewing up a natural root or leaf may also have leached out other compounds into the brew, the results of which are hard to comment on should one have methotrexate on board. Make sure you are taking folic acid (as prescribed) whilst on methotrexate. I am paranoid of my brain. It thinks all the time, even when I'm asleep. My thoughts assail me. Murderous lechers they are. Thought is the assassin of thought. Like a man stabbing himself with one hand while the other hand tries to stop the blade. Like an explosion that destroys the detonator. I am paranoid of my brain. It makes me unsettled and ill at ease. Makes me chase my tail, freezes my eyes and shuts me down. Watches me. Eats my head. It destroys me.
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DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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Wow, that is one scary medication. Found this on Medline. I don't know if it will help, but it made me pray to God that I never have to take it  Quote:
Methotrexate may cause very serious, life-threatening side effects. You should only take methotrexate to treat cancer or certain other conditions that are very severe and that cannot be treated with other medications. Talk to your doctor about the risks of taking methotrexate for your condition.
Tell your doctor if you have or have ever had excess fluid in your stomach area or in the space around your lungs and if you have or have ever had kidney disease. Also tell your doctor if you are taking nonsteroidal anti-inflammatory drugs (NSAIDs) such as aspirin, choline magnesium trisalicylate (Tricosal, Trilisate), ibuprofen (Advil, Motrin), magnesium salicylate (Doan's), naproxen (Aleve, Naprosyn), or salsalate. These conditions and medications may increase the risk that you will develop serious side effects of methotrexate. Your doctor will monitor you more carefully and may need to give you a lower dose of methotrexate or stop your treatment with methotrexate.
Methotrexate may cause a decrease in the number of blood cells made by your bone marrow. Tell your doctor if you have or have ever had a low number of any type of blood cells or any other problem with your blood cells. Call your doctor immediately if you experience any of the following symptoms: sore throat, chills, fever, or other signs of infection; unusual bruising or bleeding; excessive tiredness; pale skin; or shortness of breath.
Methotrexate may cause liver damage, especially when it is taken for a long period of time. If you drink or have ever drunk large amounts of alcohol or if you have or have ever had liver disease, your doctor may tell you not to take methotrexate unless you have a life-threatening form of cancer because there is a higher risk that you will develop liver damage. The risk that you will develop liver damage may also be higher if you are elderly, obese, or have diabetes. Tell your doctor if you are taking any of the following medications: acitretin (Soriatane), azathioprine (Imuran), isotretinoin (Accutane), sulfasalazine (Azulfidine), or tretinoin (Vesanoid). Ask your doctor about the safe use of alcoholic beverages while you are taking methotrexate. Call your doctor immediately if you experience any of the following symptoms: nausea, extreme tiredness, lack of energy, loss of appetite, pain in the upper right part of the stomach, yellowing of the skin or eyes, or flu-like symptoms. Your doctor may order liver biopsies (removal of a small piece of liver tissue to be examined in a laboratory) before and during your treatment with methotrexate.
Methotrexate may cause lung damage. Tell your doctor if you have or have ever had lung disease. Call your doctor immediately if you experience any of the following symptoms: dry cough, fever, or shortness of breath.
Methotrexate may cause damage to the lining of your mouth, stomach, or intestines. Tell your doctor if you have or have ever had stomach ulcers or ulcerative colitis (condition in which part or all of the lining of the intestine is swollen or worn away). If you experience any of the following symptoms, stop taking methotrexate and call your doctor right away: mouth sores, diarrhea, black, tarry, or bloody stools, or vomit that is bloody or looks like coffee grounds.
Taking methotrexate may increase the risk that you will develop lymphoma (cancer that begins in the cells of the immune system). If you do develop lymphoma, it might go away without treatment when you stop taking methotrexate, or it might need to be treated with chemotherapy.
If you are taking methotrexate to treat cancer, you may develop certain complications as methotrexate works to destroy the cancer cells. Your doctor will monitor you carefully and treat these complications if they occur.
Methotrexate may cause serious or life-threatening skin reactions. If you experience any of the following symptoms, call your doctor immediately: fever, rash, blisters, or peeling skin.
Methotrexate may decrease the activity of your immune system, and you may develop serious infections. Tell your doctor if you have any type of infection and if you have or have ever had any condition that affects your immune system. Your doctor may tell you that you should not take methotrexate unless you have life-threatening cancer. If you experience signs of infection such as a sore throat, cough, fever, or chills, call your doctor immediately.
If you take methotrexate while you are being treated with radiation therapy for cancer, methotrexate may increase the risk that the radiation therapy will cause damage to your skin, bones, or other parts of your body.
Keep all appointments with your doctor and the laboratory. Your doctor will order certain lab tests before, during, and after your treatment to check your body's response to methotrexate and to treat side effects before they become severe.
Tell your doctor if you or your partner is pregnant or plan to become pregnant. If you are female, you will need to take a pregnancy test before you begin taking methotrexate. Use a reliable method of birth control so that you or your partner will not become pregnant during or shortly after your treatment. If you are male, you and your female partner should continue to use birth control for 3 months after you stop taking methotrexate. If you are female, you should continue to use birth control until you have had one menstrual period that began after you stopped taking methotrexate. If you or your partner become pregnant, call your doctor immediately. Methotrexate may cause harm or death to the fetus.
"There are many paths up the same mountain."
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DMT-Nexus member
Posts: 110 Joined: 22-Oct-2011 Last visit: 24-Jan-2019 Location: colorado
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Thank you friends for replying. The medicine does seem scary, I did quite a bit of research before deciding to try it. There are also a large majority of good comments about it calling it a wonder drug. I have had arthritis since I was about 14 and nothing seems to help. This is a last ditch effort to get my pain under control. The last year or two I haven't dont DMT very much mainly because of the pain that has been attacking all of my joints. I used to have good days where I would feel really good and DMT was a pleasant idea. Any more though every single day I feel horrible with the pain and psoriasis getting worse and worse. I can only hope that it is the wonder drug that I've read about. So far I haven't had any negative side effects from it, although I haven't been taking it for very long yet. I am still in quite a bit of pain. When the pain subsides, and I start having good days again, I can return to my sacrament with a clear head, and a better feeling body. Thank you for your replies. I wouldn't do the harmalas close to the blood tests so hopefully that won't be a problem. I have stopped drinking alcohol so in some ways this medication is already helping me! Thanks again  Safe travels
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