I have noticed over the years what appears to be an interaction between stomach medicines like Imodium AD or Peptobismol and Psilicyben.
I have a weak gut and mushrooms use to tear me up. I began eating Imodium before a mushroom trip some time ago and have noticed that each time I did I barely get past threshold effects even when eating close to 4g of cubenses.
Is there any medical explanation of this or is it just random coincidence? Could these med's inhibit absorption in the stomach or intestines?

Thanks

dont they sort of coat the stomache lining? I can see how that would inhinbit full aborbtion.

Mushrooms(cubensis anyway) are really hard on my stomache as well..much moreso than ayahuasca. I dont eat mushrooms anymore ever. I only make tea. Tea does clean up this effect somewhat but not entirely..psilocybin extraction is something I am interested in, as well as blue honey..

Mushrooms in general contain chiton, which is broken down when mushrooms are cooked. The body is not capable of digesting chiton, and so raw mushrooms are really not ideal foods for the human digestive tract. Some people wont be bothered by this one bit, while others are..so if you are one of those people a making tea is a good idea.

Good to know Jaime thanks mate. I haven't had a lot of luck making tea with mushrooms. Do you need more than if eating them? It seems when I've made tea I don't get off very strongly but i would like to explore this more.

Try soaking some well cut mushrooms in lemon juie for 15mins, the add some hot water and simmer for 10more minutes.

This breakes down the shrooms nicely and makes the comeup alot quicker and the peak usually hits alot harder too

awesome tip. Thank you shroomtroll Skeemer swears by this method as well. Ill have to give it a go next time. So would a longer simmer be better or is 10 min all that is needed? Do you remove the mushrooms and just drink the tea or consume it all?

Good thread!

Immodium AD contains the opioid diphenoxylate and atropine; diphenoxylate has actions on peripheral mu receptors for example in the gut (it also crosses the BBB at higher than therapeutic doses, IIRC) and the effect on the GI tract is to slow down motility and also gastric emptying.Psilocybin is dephosphorylated to psilocin under strong acid conditions as found in the stomach due to the hydrochloric acid, and is also dephosphorylated in the small bowel by alkaline phosphatase enzymes found in the brush border formed by the epithelial cells.

IME, taking a mu receptor agonist before consuming compounds such as MDMA really does alter the experiences tempo by making it alot slower to exert its effects and I suspect this could be due to the delayed gastric emptying, particularly as taking the mu agonist 20 or so minutes after the MDMA doesnt have such an effect.I wonder if the same applies to Olys observations.

Peptobismols active ingredient is bismuth subsalicylate and its mode of action is not fully known but its thought to line the small bowel-which is useful in diarrhoea as it reduces the loss of fluid into the gut.This could reduce the ability of the alkaline phosphatase to do its work on the psilocybin, which could conceivably reduce the rate of psilocin formation, resulting in reduced effects.

This seems to make physiological sense, IMO.

I have always needed less when I make tea. It comes on faster and all at once for me.
I just powder the dry mushrooms, put them in a cup and pour boiling water over them with a little lemon..stir around and let steep for a while..then filter and squeeze all the juice from the mushrooms in the filter..add some honey if you want and drink.

I just tried this method last night with 1g of dried sygyzy cubes just to test the waters a bit.

I chopped the mushrooms up as finely as possible with some small scissors and put them in the bottom of a cup.

I added 4 drops of lemon essential oil and two cap fulls of lemon juice and allowed this to soak while I boiled 1 cup of water on the stove. Looking back I think a half a cup of water would have been a bit better.

I allowed this to seep for 15 minutes and then I filtered the tea through a cotton ball. Once all of the tea was filtered, I poured a shot of Grey Goose vodka into the funnel which acted kinda like a thp.

I combined the liquids and chugged it down. For just 1g of shrooms, I had a really nice experience. There was some stomach discomfort but not nearly as bad as raw shrooms. I ate a few crackers & donuts and that seemed to help the stomach issues a lot.

From here on out, this is the only way I'll make tea.

Doc your the man! Thank you for replying. I had a strong feeling that there is an interference taking these meds with mushrooms but didn't know if it was placebo or coincidence.

When I did my traditional Maztek mushroom velada in Mexico last fall I was worried about diarrhea during the 4 hour ceremony so i took some Imodium. The curendera said she had never seen anyone eat as many mushrooms as i had and it took hours for them to finally take effect. That's when I was pretty darn sure these meds restrict the mushrooms in some way. I ate about 5 plates of fresh mushrooms and was literally full even though I didn't eat all day from the amount of fungi in my belly!

I can't even imagine! I don't think I'd even come back.

Just another voice adding on to the "Lemon Tek" method. It is the only way I will every consume mushrooms again (assuming I have the option available, which I can't see why I wouldn't).

As others have said, it comes on fast, like within 10 minutes it is really ramping up. It seems to be a little bit stronger though perhaps the come down happens a little sooner. I used to vomit every single time I ate mushrooms and had no nausea at all. Highly recommended!

Oh and Mushrooms were not eaten, just drank the liquid and discarded the mushrooms. I just shredded them by hand a bunch and put them in a tea ball. With Fresh lemons squeezed out the juice till it covered the ball. Let that sit a little then added hot water to it and stirred it occasionally over maybe 20-30 min. I don't know that that long was necessary, I just wanted to be safe.