In shulgins Tihkal entry for DET:
http://www.erowid.org/li...ne/tihkal/tihkal03.shtmlHe states:
Apparently the MAO systems do not chomp up the dialkylamines higher than methyl.
This means the LSD-MT would possible need an MAOI to be activated! DET is used Intra Muscularly and so I wonder if it could be insulfated, I would imagine that would be way too potent to want to try, makes me think of someone trying to drop a dose in there nose! Anyone tried that before (Tangent)?
The consensus on DETs effect was of dysphoria, maybe due to setting of high survalence:
Quote:
Neurological signs varied from slight generalized tremors to gross athetoid movements. Among the bizarre somatic complaints were such as: "Air is rushing through my body," "My chest is empty and there is a jelly ball in my spine," "My hands aren't there, my whole body feels funny." All subjects experienced dizziness and increased sweating. Six of the subjects stated that the experience was an unpleasant one, three of them markedly so. There was no enthusiasm in the group for a repetition of the experience, and several stated that they would leave the clinical center before submitting to it again. A similar study with ten chronic paranoid schizophrenic patients (in the same setting and with the same dosage) produced similar effects. Most became pale, shaky, and either complained of feeling sick or actually vomiting. Several also developed tremors.
To me this is an arguement for why LSDMT would be more enjoyable. Then again
Quote:
Another study was carried out in an entirely different setting, with professional colleagues, with other professionals and with artists. These were with personal friends of the research scientists, rather than strangers to them. The observed mood changes (produced, in this study, by the i.m. administration of 0.70 to 0.80 mg/Kg of DET) were described as being in the direction of euphoria; the subjects generally enjoyed the experience and wished to repeat it. The volunteered comments under the drug tended towards the mystical and philosophical, and several of these experimental subjects responded to music and art in ways that were new to them.
Also , and I quote: It had been observed that the longer the chains on the N,N-disubstituted tryptamine, the less the potency. This means LSD-MT would be more potent.
Then he says this,which confuses me, maybe a tangent: And the longer the chains, the less of the drug was excreted as the 6-hydroxyl metabolite. This focused attention on the hydroxy metabolites of the two simplest and most potent of the dialkyltryptamines, DMT and DET.
He then writes in length of 6-HO-DMT, a minor metabolite of DMT in man.