white rabbit, you have revived an almost 3 year old thread. Then I realized I'm the one who started this thread. How naive I was back then. I saw the title of this thread, and I was going to say, "the physical effects of too much dmt will be that you get knocked the fuck out, maybe convulse, maybe vomit, lose all sense of equilibrium". But there's also unseen effects that we can only speculate. From experience with that crazy dose I took all those years ago, I had a big headache the next day. Maybe I damaged my brain a bit, who knows really? Why possibly give yourself brain damage? I woldn't take that same dose I took. It was somewhere around 500mg orally. Half that would have still been too much for me at the time. If not damaged the brain in the sense that I killed neurons, who knows what other types of damage it could have done? Maybe it affected my 5ht receptors somehow? Like overstimulating them? I don't know. I seem to be fine, and I've taken spice hundreds and hundreds of times, but who knows.
I think it's more dangerous to take a high oral dose than it is to smoke it.... although I have never personally loaded so much for a smoke, purposely trying to take as large a dose as possible. At a certain point, it'll just knock you the fug out, so there's no point in taking more. Besides, you'll usually get ktfo'd before you can smoke more anyway. There have been a few times, however when I smoked a large amount, and had trouble moving for quite a while, and getting my bearings. I was confused. However, I was also on an oral dose at the same time, so it was a lotta dmt in the brain, but I was kinda worried about some kind of permanent brain effect.... but the unusual physical and mental effects wore off with the ayahuasca. Still, wouldn't want to go in to that territory regularly. When I had these weird effects, it was in combination with l-dopa as well, an amino acid that increases dopamine levels. High dmt + high dopamine might have created a particularly potent psychoactive effect that was just too much for me to function on, resulting in a lot of confusion.