Interesting research,

https://www.sciencedaily...2019/06/190613143629.htm

It begs the question - Could gut bacteria affect psychedelic digestive breakdown and absorption?

Loveall, that's really interesting, thanks for posting..

..i personally suspect gut bacteria do have an effect on the absorption of MAOI/tryptamine brews in different individuals, depending on their gut flora, and go a step further and think they could even affect the experience, or mood in general..

Indeed, it all seems very integrated. We were discussing in chat that diet, excersice, and even travel can affect gut bacteria. It may all be intimately related.

Indeed the symbiosis 'twixt human commensal gut flora and the host is difficult to overstate. Immune functions, inflammatory balance, even mental health are effected. That said, the vast preponderance of gut microbes inhabit the colon. The stomach and upper small bowel are "essentially" sterile.

It's unlikely the pharmaco-physiologic dynamics of a RIMA+tryptaminic brew are practically modulated during the entero-hepatic phase. Obviously the impact on the CNS and the overall experience had can not be discounted. In reality, host and commensals are a unity

Peace

Very cool Loveall, just one of a massive range of variables I think when it comes to sensitivity and how we as individuals receive these drugs/plants/experiences.

And regarding exercise and gut micro [ncbi links]:

Exercise Modifies the Gut Microbiota with Positive Health Effects

Effects of short‐term endurance exercise on gut microbiota in elderly men

Physical exercise, gut, gut microbiota, and atherosclerotic cardiovascular diseases

More reason to start at some level of exercise regimen



And a few regarding gut micro and drug metabolism [ncbi links]:

The Impact of the Gut Microbiota on Drug Metabolism and Clinical Outcome

Pharmacomicrobiomics: a novel route towards personalized medicine?

The influence of gut microbiota on drug metabolism and toxicity

Very cool, tatt - interesting stuff.

One thing that could also be interesting is to try to see if/how the Ayahuasca diet and environment change the gut bacteria (if they do).

For examole could get an analysis done before a ceremonial trip to South America. Then after living there and eating the prescribed diet, get another analysis upon the return.

Any changes could be interesting to document. Researchers could look into the deltas and see if anything in there could affect the sacred drink's metabolism.

Something like that or along those lines would be interesting work I think.

Well, excessive purging is likely to have some effects. I personally prefer ayahuasca without purging, but it is certainly part of the tradition and i've heard that sometimes, purgatives are even being added.