Nothing Stops The Void
Posts: 739 Joined: 19-Jun-2008 Last visit: 26-Nov-2013 Location: Blinded by the Lye
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Have you tried ? Is there something one should know about ? I think its no problem to combine with DET , as its a chill experience . But I am not so sure about AMT , because of its stimulating properties What about DPT ? Are there any known dangers one can avoid ? Had he more quickly realized just who they were,he would have shown them more respect.Had he tried harder to fathom their brilliant minds,he would have taken more of their teachings to heart.Had he more clearly understood the purpose of their being,
he would have more vigorously tried to assist them.They were truly honorable; he was sadly prejudiced.
They were exceedingly well informed; he was grossly ignorant.They were totally indefatigable; he so often, and so quickly,gave up. Still, for many years there was a strong inter-species alliance between the Eleven-Eleven of the Half-way Realm, their Seraphic Associates,and their flesh-and-blood friend, a common mortal. Much was accomplished, many profited, and, thereโs only one regret...They could have achieved so much more...
All Hypnotizing Hypnotizes Hypnotizing
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DMT-Nexus member
 
Posts: 12340 Joined: 12-Nov-2008 Last visit: 02-Apr-2023 Location: pacific
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I have heard some bad things from people about AMT... The only person I met who liked it was some guy at a psytrance festival..and the way he described it even did not sound like my cup of tea..sounded more like a real amphetamine..not in the way mescaline is stimulating but more like a real amphetamine with some LSD like qualities. I would be very careful combining AMT with MAOI's Long live the unwoke.
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analytical chemist
  
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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fractal enchantment wrote:
I would be very careful combining AMT with MAOI's
AMT is an MAOI "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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Nothing Stops The Void
Posts: 739 Joined: 19-Jun-2008 Last visit: 26-Nov-2013 Location: Blinded by the Lye
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How strong of an Maoi is AMT , Benzyme ? Does it compare with harmine ? Can it activate dmt orally ? Tihkal wrote:In the 1960's there was quite a bit of interest at a couple of pharmaceutical houses in the indole analogues of amphetamine. Both the alpha-methylated tryptamine (AMT) and the alpha-ethylated homologue (AET) were found to be effective monoamine oxidase inhibitors, and both were clinically studied as potential antidepressants. The ethyl compound became a commercial drug, offered by the Upjohn Company as Monase, but now is considered to be without medical use and is a Schedule I drug. It is interesting that this methyl compound, AMT was also a medically available antidepressant in the Soviet Union in the 1960's and was sold under the name of Indopan, in 5 and 10 milligram tablets. (pg 567)
Seems to be a clear contraindication . @fractal I know several people who liked AMT , okay granted they are several people from psytrance festivals  What about DET and DPT ? Do you think they are safe to enhance with Harmaloids ? DET at least felt safe ... Had he more quickly realized just who they were,he would have shown them more respect.Had he tried harder to fathom their brilliant minds,he would have taken more of their teachings to heart.Had he more clearly understood the purpose of their being,
he would have more vigorously tried to assist them.They were truly honorable; he was sadly prejudiced.
They were exceedingly well informed; he was grossly ignorant.They were totally indefatigable; he so often, and so quickly,gave up. Still, for many years there was a strong inter-species alliance between the Eleven-Eleven of the Half-way Realm, their Seraphic Associates,and their flesh-and-blood friend, a common mortal. Much was accomplished, many profited, and, thereโs only one regret...They could have achieved so much more...
All Hypnotizing Hypnotizes Hypnotizing
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DMT-Nexus member
Posts: 12340 Joined: 12-Nov-2008 Last visit: 02-Apr-2023 Location: pacific
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benzyme wrote:fractal enchantment wrote:
I would be very careful combining AMT with MAOI's
AMT is an MAOI I guess I meant combining it with harmala alkaloids..simply taking more AMT on top of another dose of AMT I would think would differ from adding harmalas to AMT.. I am not saying it cannot be done..but it might be too stimulating nad uncomfortable etc.. I was going to try AMT a while back..but decided not to after talking to some other people. Long live the unwoke.
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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Observant wrote:How strong of an Maoi is AMT , Benzyme ? Does it compare with harmine ? Can it activate dmt orally ?
depends on the dosages and half-lives.. binding affinity and duration of action. they're both reversible inhibitors, which are fine. just play it safe.. always avoid irreversible inhibitors like Nardil. and yes, I'd imagine dmt would be orally active with IT-290 "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 114 Joined: 03-Nov-2008 Last visit: 10-Aug-2014 Location: mid USA
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fractal enchantment wrote:I have heard some bad things from people about AMT...
The only person I met who liked it was some guy at a psytrance festival..and the way he described it even did not sound like my cup of tea..sounded more like a real amphetamine..not in the way mescaline is stimulating but more like a real amphetamine with some LSD like qualities.
I would be very careful combining AMT with MAOI's thats pretty much how it felt to me... supposedly at higher doses it's more psychedelic and less speedy, but i never felt comfortable enough to take it that far(i dont like stimulants, i have mild anxiety). ...only tried it a few times, several years ago. apparently some people really enjoy it, though.
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DMT-Nexus member
Posts: 1055 Joined: 18-Jan-2008 Last visit: 09-May-2010 Location: Darkest Night
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DPT no problem done it many times. You will be purging on a moderate dose and up. The most I did wad 250mg with 7grams rue. It blew my head right off was quite uncomfortable from the onset thru and a bit past the purge then it was enjoyable. IM is the way to go with DPT bypass the stomach and the side effects are dramatically reduced. Its a trip but I never got profound mental effects like the other classic psychedelics. I have also rue combo with numerous other tryptamines and found no trouble. Now that does not mean it is safe but I have never had any issues with it. Every tryptamine I have ever come across I have combo as well no apparent ill effects for me. I do not like speedy AMT so I never did that one that is because I do not do AMT PEACE MV
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The Great Namah
Posts: 3433 Joined: 18-Jan-2008 Last visit: 17-Sep-2020 Location: The place entites go when they smoke allspice
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Honestly, not enough is known about these synthetic tryptamines to be able to say "yes it is safe". Some of the tryptamines might not be safe by themselves, much less with an MAOI. I would avoid the combinations completely. Stretching your $ or £ or ¥ with an MAOI is not worth your life! The Spice extends life
The Spice expands consciousness
The Spice is vital for space travel
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Never underestimate the power of STUFF!
I am certifiably insane, as such all posts written by me should be regarded as utter nonsense or attempts to get attention.
I don't know SWIM and personally don't trust him at all. If SWIM is posting, most likely I will not respond...as I said, I don't trust the guy. YOU I trust, but never SWIM.
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DMT-Nexus member
Posts: 3555 Joined: 13-Mar-2008 Last visit: 07-Jul-2024 Location: not here
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Yes agonists of seretonin receptions combined with things that inhibit the break down of seretonin as well as the break down of the agonists can cause seretonin syndrome which can be life threatening. Many safe combinations of tryptamines and MAOI's are already known so its best to stick with those (acid shrooms dmt etc). The pharmacology of some of these research tryptamines is still largely unknown.
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