Thats an interesting suggestion that it may be influenced by what is already in the GI tract before dosing.
I dont always get delayed or dual onset but it is common, and I have always dosed after fasting for around 19 hours [I prefer to do all drugs in a fasted state, even coffee. If I ever need to loose weight it would be as easy as a bottle of 80mg mescaline pills
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I could try breaking that habit with DMT by consuming a banana and some juice or a spoon of honey an hour or two before dosing. I know from multiple day fasts that unsweetened black decaf coffee wont take me out of fasting mode, but a banana and juice sure will!
Last night I played with THH dose and timing [100mg at T-2:00 and 100mg at T-1:00 so I would go into a THH peak as I was dosing the DMT and again as peaking on the DMT] and a DMT peak hit me fast at 60 minutes. I managed a piece of sweet ginger at +1:30 and some strawberries at +2:00 and went into a strong second peak around +3:00. I think it took my body that long to come out of fasting mode. The same happens with mescaline, if I eat an apple too early in the trip it can give me a stomach ache and take an hour or two to start digesting. So it follows that one option would be to just not be in fasting state before dosing.