I believe that powerful psychedelics can make you mad if used improperly. whenever I hear someone say anything different I think to myself this person has never taken a heroic dose. psychedelics are nothing to play around with and should be treated with respect. This is just my opinion so don't flip out on me lol.

I get this, however this guy was psychotic for months and didn't specify if he ever went back to baseline or if he was stuck being psychotic. Too me it seems very unlikely to happen to a sane person no matter the dose which in his case was low already.

The primary health concerns about LSD use are related to psychological health rather than risk of physical damage to the body or brain. As senior LSD researcher Dr. David Nichols, Distinguished Chair of Pharmacology at Purdue University and head of one of the world's top LSD research labs, stated in his 2004 review article on hallucinogens, "There is no evidence that any of the hallucinogens, even the very powerful semisynthetic LSD, causes damage to any human body organ. [...] Hallucinogens do not cause life-threatening changes in cardiovascular, renal, or hepatic function because they have little or no affinity for the biological receptors and targets that mediate vital vegetative functions."1 Deaths resulting from the pharmacological effects of LSD are rare to non-existent.

However, like all psychoactive drugs, LSD can induce cognitive and emotional alterations that can greatly affect behavior. With psychedelics such as LSD, there can be powerful and unexpected changes in thinking and perception. While under the influence of these drugs, an individual can exhibit poor judgement and delusional behavior, leading to accidents or dangerous situations. In those individuals predisposed toward certain psychiatric conditions, hallucinogens may precipitate psychotic responses or depression. In some individuals, long-lasting anxiety and/or depression may result from the unpleasant experiences and frightening visions that occurred during the psychedelic experience.
https://www.erowid.org/c...als/lsd/lsd_health.shtml

Precipitation of Psychosis. LSD may have the ability to trigger psychotic symptoms in those predisposed to psychosis. This is problematic because psychotic or schizophrenic disorders most frequently manifest in those in their late teens or early twenties, the same age that use of LSD is most common. Individuals with a family history of schizophrenia or early onset mental illness should be extremely careful because LSD is known to trigger latent psychological problems. "Fortunately, however, these drugs do not appear to produce illness de novo in otherwise emotionally healthy persons, but these problems seem to be precipitated in predisposed individuals."1 This adverse event is apparently quite rare: as Dr. Nichols of Purdue University observed in 2004: "A search of Medline in early 2003 for case reports of LSD-induced psychosis found only three reports in the previous 20 years."
https://www.erowid.org/c...als/lsd/lsd_health.shtml

I started thinking that years ago when I was reading a trip report of someone who ate something like 2 grams of mushrooms, and the person claimed that they started to see their friend crying blood and was horribly traumatized for months. It sounded like the script out of a cheesy horror film.

Robert Bergman, MD, in "Navajo Peyote Use: Its Apparent Safety," _Amer.
J. Psychit. 128(6):51-55/695-699, writes:

"Some rough estimates of the rate of negative reactions to peyote can be
made. The Native American Church of Navajoland estimates its membership
at 40,000. This estimate may be high and there may be inactive members,
so we will use a population base of 30,000. Our informants report attending
meetings with an average frequency of about twice a month. Since this may
be exaggerated, we will assume an average attendance of only once every
two months. This would result in a total of 180,000 ingestions of peyote
per year by the population we serve. Assuming that all five of our cases
represent true reactions to peyote and that we hear about only half of
the cases occurring, the resulting (probably overestimated)rate would
be approximately one bad reaction per 70,000 ingestions."

https://erowid.org/plant...eyote/peyote_info3.shtml

There have been no verified human deaths from mescaline ever, although K. Trout states that there is one unconfirmed (and unconfirmable) report of a person who died during military experiments with the drug, after receiving a 15 gram dose intravenously (or about 150-200mg/kg).

In experiments with rats, the LD50 for mescaline has been established in the range of 800-1200mg/kg orally.

Considering the human dose of mescaline is around 200-500mg orally, this means you would have to try very hard to take a fatal dose. It would be extremely unlikely to happen accidentally.
https://erowid.org/ask/ask.php?ID=1778

The primary health concerns about LSD use are related to psychological health rather than risk of physical damage to the body or brain. As senior LSD researcher Dr. David Nichols, Distinguished Chair of Pharmacology at Purdue University and head of one of the world's top LSD research labs, stated in his 2004 review article on hallucinogens,

"There is no evidence that any of the hallucinogens, even the very powerful semisynthetic LSD, causes damage to any human body organ. [...] Hallucinogens do not cause life-threatening changes in cardiovascular, renal, or hepatic function because they have little or no affinity for the biological receptors and targets that mediate vital vegetative functions."1 Deaths resulting from the pharmacological effects of LSD are rare to non-existent.

https://www.erowid.org/c...als/lsd/lsd_health.shtml

Fortunately, however, these drugs do not appear to produce illness de novo in otherwise emotionally healthy persons, but these problems seem to be precipitated in predisposed individuals."1 This adverse event is apparently quite rare: as Dr. Nichols of Purdue University observed in 2004: "A search of Medline in early 2003 for case reports of LSD-induced psychosis found only three reports in the previous 20 years.
https://www.erowid.org/c...sd/lsd_health.shtml#ref1

Precipitation of Psychosis. LSD may have the ability to trigger psychotic symptoms in those predisposed to psychosis. This is problematic because psychotic or schizophrenic disorders most frequently manifest in those in their late teens or early twenties, the same age that use of LSD is most common. Individuals with a family history of schizophrenia or early onset mental illness should be extremely careful because LSD is known to trigger latent psychological problems. "Fortunately, however, these drugs do not appear to produce illness de novo in otherwise emotionally healthy persons, but these problems seem to be precipitated in predisposed individuals."1 This adverse event is apparently quite rare: as Dr. Nichols of Purdue University observed in 2004: "A search of Medline in early 2003 for case reports of LSD-induced psychosis found only three reports in the previous 20 years."
https://www.erowid.org/c...als/lsd/lsd_health.shtml

The primary health concerns about LSD use are related to psychological health rather than risk of physical damage to the body or brain. As senior LSD researcher Dr. David Nichols, Distinguished Chair of Pharmacology at Purdue University and head of one of the world's top LSD research labs, stated in his 2004 review article on hallucinogens, "There is no evidence that any of the hallucinogens, even the very powerful semisynthetic LSD, causes damage to any human body organ. [...] Hallucinogens do not cause life-threatening changes in cardiovascular, renal, or hepatic function because they have little or no affinity for the biological receptors and targets that mediate vital vegetative functions."1 Deaths resulting from the pharmacological effects of LSD are rare to non-existent.

However, like all psychoactive drugs, LSD can induce cognitive and emotional alterations that can greatly affect behavior. With psychedelics such as LSD, there can be powerful and unexpected changes in thinking and perception. While under the influence of these drugs, an individual can exhibit poor judgement and delusional behavior, leading to accidents or dangerous situations. In those individuals predisposed toward certain psychiatric conditions, hallucinogens may precipitate psychotic responses or depression. In some individuals, long-lasting anxiety and/or depression may result from the unpleasant experiences and frightening visions that occurred during the psychedelic experience
https://www.erowid.org/c...als/lsd/lsd_health.shtml

Before I continue with the story of the peyote trip that ruined my life, I must mention that 2 or 3 days before I took the peyote I had candy flipped (shrooms and mdma) which I have done plenty of times without any adverse reaction. This may or may not have contributed to the peyote trip, but regardless, after the candy flipping I was fine until the Peyote.

We complete the ceremony in the morning, and I am invited to another ceremony at a different location the next night.

So any way, all this shit all because of a little Peyote.

The Native American Church isn't evil. It is just misinformed. Peyote has very negative potential, and has been the most detrimental drug I have ever taken.

I don't want to have to face that again where I am in my life atm because I never wish to feel that lonely, helpless and desperate ever again.

These things can shake you up.