We don't get headaches, but we get this sometimes.....

(lookup Scintillating Scotoma )

(definitely triggered by GHB)

And I thought I was the only one...

I get these often ... I actually like em now.
I call it getting an 'Attack of the Rainbows'

25 minute colourful light show (with some sucky after effects)
Great if you don't mind going Blind for half an hour
Not so great if you're driving ...

Welcome to the Rainbow Club Intezam

at first we really thought we was going to be blind

We think we have found a way to make it go away (in 5 min): Drinking a large amount of cold water (750ml).

GHB?

The mechanism of action of ergotamine is complex.[5] The molecule shares structural similarity with neurotransmitters such as serotonin, dopamine, and epinephrine and can thus bind to several receptors acting as an agonist. The anti-migraine effect is due to constriction of the intracranial extracerebral blood vessels through the 5-HT1B receptor, and by inhibiting trigeminal neurotransmission by 5-HT1D receptors. Ergotamine also has effects on the dopamine and norepinephrine receptors. Its side effects are due mainly to its action at the D2 dopamine and 5-HT1A receptors -Wikipedia

UML-491, Methysergide, Sansert. This is the synthetic homologue of methergine (1-methyl) and is employed clinically as a treatment for migraine headaches. When the usual therapeutic dosage of two milligrams is scaled up by a factor of ten, there is a profound LSD-like response described by most subjects. A number of these ergot analogues from nature can be considered as potential precursors for the preparation of LSD. But here, there is a 1-methyl group that is effectively permanently attached, so it cannot play this role. -TIHKAL;shulgin

triptans mechanism of action: Their action is attributed to their agonist[18] effects on serotonin 5‑HT1B and 5‑HT1D receptors in blood vessels (causing their constriction) and nerve endings in the brain, and subsequent inhibition of pro-inflammatory neuropeptide release, including CGRP and substance P. Triptans are selective agents for 5-HT1B and 5-HT1D[18] and have low or even no affinity for other types of 5-HT receptors. -Wikipedia

EG - triptans (which work very well, I've been Rx'd two) are selective for migraines, and occasionally cluster headhaches. From my review of the literature, I think that the the vascular hypothesis is on it's way out and that it was more to do with inter-regional signaling in the brain mediated by 5-HT receptors, but no one knows for sure.

They're not indicated or other kinds of headaches though.

Blessings
~ND

Their action is attributed to their agonist effects on serotonin 5‑HT1B and 5‑HT1D receptors in blood vessels (causing their constriction) and nerve endings in the brain, and subsequent inhibition of pro-inflammatory neuropeptide release, including CGRP and substance P. Triptans are selective agents for 5-HT1B and 5-HT1D[18] and have low or even no affinity for other types of 5-HT receptors.

Abstract
Recent studies of the pathophysiology of migraine provide evidence that the headache phase is associated with multiple physiologic actions. These actions include the release of vasoactive neuropeptides by the trigeminovascular system, vasodilation of intracranial extracerebral vessels, and increased nociceptive neurotransmission within the central trigeminocervical complex. The 5-HT1B/1D receptor agonists, collectively known as triptans, are a major advance in the treatment of migraine. The beneficial effects of the triptans in patients with migraine are related to their multiple mechanisms of action at sites implicated in the pathophysiology of migraine. These mechanisms are mediated by 5-HT1B/1D receptors and include vasoconstriction of painfully dilated cerebral blood vessels, inhibition of the release of vasoactive neuropeptides by trigeminal nerves, and inhibition of nociceptive neurotransmission. The high affinity of the triptans for 5-HT1B/1D receptors and their favorable pharmacologic properties contribute to the beneficial effects of these drugs, including rapid onset of action, effective relief of headache and associated symptoms, and low incidence of adverse effects. http://jamanetwork.com/j...ology/fullarticle/782346

5,N,N-trimethyltryptamine (5,N,N-TMT; 5-TMT) is a tryptamine derivative that is a psychedelic drug. It was first made in 1958 by E. H. Young. [1] In animal experiments it was found to be in between DMT and 5-MeO-DMT in potency [2][3] which would suggest an active dosage for humans in the 20–60 mg range. Human psychoactivity for this compound has been claimed in reports on websites such as Erowid but has not been independently confirmed -Wikipedia

EG - triptans (which work very well, I've been Rx'd two) are selective for migraines, and occasionally cluster headhaches. From my review of the literature, I think that the the vascular hypothesis is on it's way out and that it was more to do with inter-regional signaling in the brain mediated by 5-HT receptors, but no one knows for sure.

They're not indicated or other kinds of headaches though.

Blessings
~ND

These mechanisms are mediated by 5-HT1B/1D receptors and include vasoconstriction of painfully dilated cerebral blood vessels, inhibition of the release of vasoactive neuropeptides by trigeminal nerves, and inhibition of nociceptive neurotransmission. The high affinity of the triptans for 5-HT1B/1D receptors and their favorable pharmacologic properties contribute to the beneficial effects of these drugs, including rapid onset of action, effective relief of headache and associated symptoms, and low incidence of adverse effects. http://jamanetwork.com/j...ology/fullarticle/782346

Flash's Method for Using Psilocybin Mushrooms to Treat Cluster Headaches
(In Experience Report Vaults)
by Flash

First I eat a large meal, then I wait 2 hours, this prevents stomach upset and excess gas. Next I extract 12 mushrooms (the standard recreational dose is 4 [erowid note: this is done in the U.K. and these mushrooms are psilocybe semilanceata] and add them to a saucepan along with 1 cup of boiling water. I boil the mushrooms for 5-10 minutes (the illegal part) then strain them out and bin them. Next I consume a large glass of whiskey. The whiskey both induces a headache, and eliminates any feelings of apprehension caused by ingesting the Psilocybin solution. Finally I drink the solution slowly, over a 15 minute period, to prevent any disorientation. The mushrooms kick in when the headache is going full blast. There is a sudden feeling of "ooh that's better" and then no more headache. No more headaches for at least 12 months in my case. There are no psychosomatic side effects to speak of, apart from once when I had a giggle fit... https://erowid.org/plant...dical1.shtml#FlashMethod

We don't get headaches, but we get this sometimes.....and it also sucks.