dragonrider & peeps, this should be of interest regarding Voacanga africana extraction and ibogaine production, from some of my email exchange with ibogaine expert Dr Chris Jenks.
"In my own studies, acetic acid doesn't remove alkaloids from root bark as fast as dilute HCl does, but I don't know if that matters in extracting alkaloids from solvent. Actually, based on my recent work with Voacanga, I would expect acetic acid to be most likely to leave behind voacangine in the limonene extract because that is the least basic alkaloid. That's not a bad thing since voacangine seems to only cause stomach aches.
You can extract powdered Voacanga bark with a non-polar solvent and remove most of the more basic alkaloids with weak acid like dilute acetic acid, then remove the weak bases like voacangine with a strong acid like HCl. Bob Sisko uses toluene for the initial extraction of root bark, showing that this is feasible. However, on the scale needed to make a difference in the market it would be much more economical to extract the bark with strong dilute acid and recover them by precipitation with base - or make the extract less acidic and extract out voacangine directly. The only other thing I would like to emphasize, although it is covered in the above presentation, is that these extractions need to be repeated to be efficient, just as the extraction of iboga bark with dilute acid is best repeated at least six times."
...so selective use of solvents may produce a cleaner alkaloid profile from the Voacanga.
A link here (which needs updating), but it might be worth contacting Chris about this:
https://www.ibogainealli...ogaine-production-guide/There will definitely be some visionary overlap between high dose harmaline and ibogaine...the former in some sense may be more user friendly and less time demanding, but one highly experienced iboga practitioner (who introduced me to it), described a hangover lasting days after experimenting with really high doses of harmaline. Ibogaine can produce a hangover before one managed to fall asleep, but post sleep for many there is a noticeable (and prolonged) afterglow (although I did not experience this after experiencing pure ibogaine, only TA and root bark). Both substances have the potential for neurotoxicity, but in ibogaine's case, the dosage levels required for this would likely already be causing some pretty hefty physiological toxicity issues anyway...I'm not sure at what dosages harmaline would start to become neurotoxic.