So I was reading about rectal administration recently, and tried it with Bacopa with surprisingly good results. But I can't find much info on this, how safe is rectal administration of substances and extracts? Could I also use Lion's Mane extract?
These substances don't feel as rough as some drugs people use this way...

here is an answer I snatched from reddit

Plugging is my preferred administration of pills and MDMA. Dissolve around 80% of your preferred oral dosage in warm water/whatever your substance is soluble in, draw into an oral syringe, and insert into your rectum. After pressing the plunger, lay on your stomach for around 10 minutes so that it can onset. It should come on just slightly slower than snorting, and be a bit more potent. It is about as safe as snorting, however be sure to lubricate the syringe to avoid tearing of any sort. As for the long term side effects, it depends on the substance and it's fillers, as well as how caustic it is."

So plugging stuff like Bacopa Monierri for instance would be dangerous as it is notorious for heavy metal toxicity. On the other hand, Lion's Mane could be a safer option.

Still these waters look shady stay safe people...

Dude, you're going the wrong way! (p.s. you got smelly fingers?)

If you want to experiment with it then go ahead.
Just dont forget that puttin stuff up your butt may have unwanted side effects like itching and liquid expulsions .

I dont think its better than sublingual. But if you are unable to have the substance in your mouth its an option. Also there is no reason to do it for most drugs because you just end up numbing your butt. And also poking around down there isnt something annyone wanna do when you are taking something while you have friends over

Also if you stuff something like salvia leaf it will be a mess to get out later.