I've been looking into these DMT homologues recently:

•alpha,alpha,beta,beta-tetradeutero-N,N-dimethyltryptamine ( D4DMT )
(This compound is said to produce an experience that is more intense and for a longer duration that proteo-DMT. "It was observed that the presence of deuterium in the alpha- and beta-positions of the ethylamine side-chain led to a potentiation of the level of DMT in brain" )

•5-Bromo-N,N-Dimethyltryptamine (5-br-DMT)
(5-Bromo-DMT and 5,6-dibromo-DMT are found in the sponges Smenospongia auria and S. echina resp. I have no idea if they are active by smoking (the 5-Br-DMT just might be)-Alexander shulgin TIHKAL. Aside from shulgins speculation that 5-Br-DMT May be active when smoked I've found that this compounds Wikipedia page states "Anecdotal reports published by Hamilton Morris indicate that 5-Bromo-DMT freebase is psychoactive in humans when smoked at doses between 20 and 50 milligrams" all and all I would say that this compound looks very promising)

•1-methoxy-N,N-dimethyltryptamine (lespedamine; 1-MEO-DMT)
( The compound with a methoxy group substituent at the 1-position is called Lespedamine, 1-MeO-DMT. With an NO bond, this should be classified as a substituted hydroxylamine. I would love to know if anyone anywhere has ever tried smoking it. I suspect it might very well be active, but it is, to my knowledge, untried. -Alexander shulgin TIHKAL)

•4,5-methylenedioxy-N,N-Dimethyltryptamine (4,5-MOD-DMT)
(Because positions 4 and 5 are your key positions for substitutions on the DMT molecule I would be very interested in learning if this compound is active in humans. As of now there does not exist any published human bioassays or any reports of human pharmacology, but because of this comment made about the closely related compound 4,5-MOD-DIPT "25 mg, orally) Nothing much happened for about 3 hours, and then I suddenly shot up. I was at the plateau for a fair time, the recovery was difficult to define chronologically. This was in daylight; I was reminded very much of LSD." I am hopeful that 4,5-MOD-DMT will be an active and novel psychedelic compound.

I have also had very much interest in using ULM-491 (1-methyl-d-lysergic acid butanolamide) as a primer to DMT because of these comments that Alexander shulgin in TIHKAL: "A study conducted on 40 normals, this in Hungary some 30 years ago, found that the administration of 40 mg quantities to be symptom free. With several of the experimental subjects in this study, the DMT was preceded by the administration of 1-methyl-d-lysergic acid butanolamide (UML-491), a potent serotonin antagonist. This was given either orally (1-2 mg 30 to 40 minutes before) or intramuscularly (0.5 mg 10 minutes before). This served to greatly intensify the effects of the DMT, with intense and agitated hallucinations, highly intensified colors, and a more extreme loss of time and space perception. It was assumed that UML-491 was inactive, but recent trials indicate that there can be central effects produced. It is discussed in the entry for LSD."
From what I can glean from shulgins statements ULM-491 greatly intensifies the effects of DMT when taken prior to its administration.

If anybody has any information, ideas, experiences, comments, etc.... regarding these compounds it would be much appreciated.

Also if there are any DMT homologues or analogues that you feel would be of interest to me please feel free to suggest them.

Thanks,

-EG

For the methylenedioxy compounds my auto correct changed MDO to MOD.
I apologize for not catching the error before I posted.

-EG

After discussion in another thread I realized that the nomenclature I used may have been some what confusing, so just to clear things up:

this is the definition of homologue that I'm using:

In chemistry, a homologue is a series of compounds with the same general formula, usually varying by a single parameter—such as the length of a carbon chain.

In example, take lysergic acid diethylamide, if you extend the carbon chain from the nitrogen at position 6 from a methyl to an ethyl chain you have produced 6-ethyl-6-nor-lysergic acid diethylamide, or ETH-LAD, which by the definition above is a homologue of LSD.

With alpha,alpha,beta,beta-tetradeutero-n,n-dimethyltryptamine or D4DMT for short the only differences are isotopes of hydrogen, so D4DMT and DMT are homologues.

If the Core structure of the compound is present, only some very small change has occurred, I use the word homologue, when two unrelated compounds produce identical effects I use the word analogue, that is Unless I'm publishing a research paper or doing something where nomenclature really matters.



-EG

Is there a reason you keep posting this same wall of text over and over? You posted in in the RU-38206 topic, the 'just a thought' topic, and it appears twice here?

If people have information about these things, I'm sure they'll post it.

Blessings
~ND

I thought is was only here, and in one more thread.

I think the other thread involved chemistry of novel compounds, so I assumed that perhaps if these people are knowledgeable when it comes to other novel compounds, that they may have some information on the compounds I'm looking into.

There's been times when I got no response to something, and a few months later I will re-post it and locate the information I was seeking.

-EG