I suppose the remedy would vary with the specific discomfort. Stretching/flexing, massage, dancing/moving in rhythm, drinking liquids, and changing the pattern of breathing are techniques that can be useful to resolve unpleasant physical restlessness, physical feelings associated with being emotionally choked up/tight chest, asthma/flu-like symptoms, unsettled stomach, dizziness, and skin crawling or formication. You might also try the ol' boot-n-rally. Do all of these at simultaneously for best results