Many of us love and respect DMT for the amazing molecule that it is. It allows us to traverse interesting realms that in many cases lead to personal revelations.

But as pharmacological research continues, I can't help but wonder: will a more powerful molecule emerge one day that overshadows DMT? We are learning so much about our brains, bodies, and the chemicals that influence them, but DMT seems to have a special place as an endogenous yet psychoactive chemical.

Are there any other known endogenous chemicals that could have a similar, if not more powerful, effect? Or do you think it is possible to design a new molecule eventually that will allow us to travel spaces that were previously unknown?

5meo and bufotenine are also endogenous and purportedly on par with dmt (arguably of course). For the former there are not readily available plant sources and for the latter extraction and purification is not as straightforward/developed as dmt.

What I am trying to say is that maybe one reason why a lot of folk in the nexus think that dmt is so amazing might relate to how easy it is to acquire dmt as opposed to e.g. other compounds.

This is basically what Sasha Shulgin dedicated his life to.

https://en.wikipedia.org/wiki/TiHKAL

https://en.wikipedia.org/wiki/PiHKAL

I've read a few reports that DPT is arguably just as powerful and profound as DMT, if not more. However, I've also read that the experiences aren't as spiritual feeling as DMT and as far as I've read, they are usually very weird. However, this molecule is already orally active without an MAOI and the smoked effects last longer than DMT so to me it's definitely something to look into. Google some DPT experiences and you'll see what I mean by the weirdness

For the love of God, what could be possibly more intense than N,N experience?

But again, such question might be stupid. It is not unreasonable to assume that there's even more. But if there is...damn I can't even conceive of such thing.

Haha I feel you here! I'm thinking about my furthest out experience.... One where I ZOOMED right past what I would call "hyperspace"... The land with the beings and machines and all that and just kept going and going and going and going through this tunnel and popped out in a place that I honestly can not remember at all. All I remember was thinking "Oh no I went way too far this time oh my god I'm not supposed to be here I'm not supposed to see any of this how am I going to get back?!" ..... If there's a molecule that takes me farther than THAT I don't know if I want to even try it

What does a more powerful molecule mean? DMT just seems to stand out because it is such an intense experience in such a short amount of time, and its use in aya. But they also use Iboga and Datura in aya also. I think all psychoactive compounds have the same amount of potential for a person to have a spiritual insight. Terrence Mckenna points out in his book Food of the Gods that in shamanism, a shaman who eats a ton of hot peppers under the blazing sun is just as equal in his presence in the spiritual plane as a shaman on aya.

Exactly. More powerful how? Technically, LSD is "stronger" than DMT because you need less of it to achieve an effect. But the experience DMT provides, as well as the insights I've gained from it, are worlds above any insight I've gained from the use of LSD. To be fair, I don't have a lot of experience with Lucy.

As in more powerful, I mean having the ability to launch you out further and put you in a state that seems even more incomprehensible than what we have come to call hyperspace. There are many posts on the Nexus that discuss hyperspace and experiences with entities, and these appear more powerful to me than one taking LSD and "seeing leafs rustle in the wind and realizing we are all one." This may be more profound, but not as alien.

I did look up a couple DPT trips - that is some funky stuff too! However one of the challenges I see with a lot of these chemicals is that they can sometimes prevent you from remembering your experience. As I have said before, if I can't remember something, then it doesn't help me at all. So it's a balancing act between ego dissolution, intensity, alien-ness, and being able to remember what occurred.

DMT is so special IMO because of its endogenous status and the possibility that it plays a role in some of our naturally occurring mystical experiences. But maybe there are other psychoactive compounds, like 5meo and bufotenin as Infundibulum mentioned, that exist within our brains that facilitate these interactions. Time and science will unlock some truths, but there may be hidden answers now...

Im pretty sure 1mg of LSD would throw you out farther than 50mg of dmt.

I feel like the psychs we currently use are about as hardcore as the human brain can handle.

Once a doorway is wide enough for you to easily pass through, what benefit is there to widening it further?

This reminds me of that quote by that guy that had something to do with hanging up the phone after you get the call...I think. I don't have a great memory.

Salvorin A comes to mind, and ibogain, and certainly many others are waiting tobe discovered.

So that i can drive through with my pickup-truck of course.

Other different plants and DMT derivatives(based on reports) have been and certainly could be on par with what N,N-DMT can do.

I agree. S.divinorum comes really close.. being similar in duration, acuity of effects etc. And yes, much moar to see and learn!