Great question by Gammagore.

I tried it many years back when I was SCI. It was in the presence of two doctors and other friends in a social rather than medical situation. I got spasms, particularly in the legs which jittered away for a few hours. I found that part eventually exhausting but also I had time to revolutionise my appreciation of music.
Acid seems to heighten the intensity of wherever you put your mind. So if you get scared of the spasms you will likely get very scared. If you put your attention elsewhere then you are more likely to forget about the spasms (for a while, at least).
So, I'd agree that it does have the risk of an additional discomfort for SCI people.
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Way back before E became popular and it was doing the rounds of fringe psychotherapists involved particularly in couples counseling, I tried it a couple of times. On the negative side it seemed to prevent my bladder firing (back then I voided off pressure/reflex) and I wondered if it was causing pressure on the kidneys. On the good side I would put it right up there with the most positively significant experiences of my life. It allowed me to get in touch with the depth of my loving and I've been riding on the confidence of that ever since.
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I've only ever taken LCD in the company of medical doctors (off duty) and I don't ever intend to try it again. The several "experiments" were richly rewarding but I too got strong spasms, leaving me exhausted. What I had was worth it but I'm no longer interested to go through that again.

A couple of other times I had E with those same supports. Spasm was present but not too bad. The experience changed my life for the better, possibly the most significant realization in my life. But I felt drained the next day and I wouldn't do it again. I don't think it did my body any good.

Mushrooms was a different situation - I was travelling and less responsible with the risk. The first time in Mexico was miserable, hours of exhausting spasms on a river bank which is not a safe environment. A couple of later experiences were in a safer situation and were rather gentle. But the danger of mistakenly eating a poisonous fungi is not worth doing it again.

Any SCI person dabbling with these hallucinogens should be very cautious because it's obvious that strong spasms are common and may hinder breathing or cause severe bruising. Anyone still intending to experiment should go to great lengths to ensure a super safe environment including soft surroundings and knowledgeable friends with you.

So last month, a bunch of us took some E. I typically dont get spasms in my legs but while 'rolling' I had too much going on that i couldnt "get out" my legs ended up stretching themselves out and bouncing alot. Everyone thought I was doing it at first cause it looked so natural. I had to swear I couldnt! My poor friend Jason, I had my feet in his lap as we sat outside, and with every stretch of the legs he got his balls crushed! Oh man it was funny. You think we would have just moved my feet but NOOOOO.. we're dumb and it was funny!

I have to admit I totally figured with such a lack of sensation below my injury, and my muscles going nuts. I for sure thought I would piss myself or something gross. Thank god I didnt!

i would limit the advice of not drop an acid to sci from T5 and higher.. because we dont have our autonomic nervous system working. and drugs normally mess with temperature, blood pressure and other functions regulated by this ANS.
as for the spasms, they are exagerated by one of the side effect caused by pne of the components of a pill of ecstacy, strychnine. strychnine caused spams even in AB because it blocks the inhibitory signs to the muscles, kind of the way a sci does..

I'm a C5-C6 complete and So I've had trouble with the spasms too while tripping either acid or mushrooms. My legs sticking straight out and shake relentlessly and my only fix is to strap them to my chair with a belt. My abdomen and back were flexing back and forth, I did have to urinate a lot so a condom cath helps. The worst parts are my fingers clenching (quad's) and the heating up. Once I was tripping outside in cold cold weather with no shirt on and still hot. And you know how most quads are, so I knew this was not normal.

Don't get me wrong I did love it you feel so free and clear, but this is a big risk. So remember KNOW YOUR BODY, KNOW YOUR MIND, KNOW YOUR DRUG. Be absolutely sure some one will be with you to help and DON'T go out in public.

My scientific theory for what causes this is that Psychedelics like acid even E cause a random synapse or firing of the nerves in your brain and cerebrum which controls a lot of bodily functions. So when one doesn't have any control over the firing of nerves linking to the control of paralyzed limbs in the first place and acid is introduced and causes random firing you get CRAZY spasms for 6 HOURS straight.

So if your in it deep I say take meds for spasms, stay cool (wet towels work), and enjoy the ride.