However, in a broad (as yet unpublished) survey of Banisteriopsis caapi, Psychotria viridis and subsequent teas, which included phytochemical analyses of all, plus subjective ratings of the teas, a strong correlation was found with teas that contained high amounts of THH and not DMT! This rating was from a large body of experienced users (regular União do Vegetal members who had consumed ayahuasca for 10+ years).

More studies on tetrahydroharmine are absolutely imperative

Breadth of Receptor Binding, 4.00=max, 0.00=min

LSD: 5ht1a = 3.73, DMT: = 0.00, psilocin = 2.88, mescaline = 3.61
LSD: 5ht1b = 4.00, DMT: = 0.00, psilocin = 2.19, mescaline = 0.00
LSD: 5ht1d = 3.70, DMT: = 3.91, psilocin = 3.40, mescaline = 0.00
LSD: 5ht1e = 2.62, DMT: = 3.28, psilocin = 3.03, mescaline = 3.16
LSD: 5ht2a = 3.54, DMT: = 2.58, psilocin = 2.14, mescaline = 0.00
LSD: 5ht2b = 3.11, DMT: = 3.91, psilocin = 4.00, mescaline = 3.97
LSD: 5ht2c = 3.11, DMT: = 3.42, psilocin = 2.52, mescaline = 0.00
LSD: 5ht5a = 3.64, DMT: = 3.16, psilocin = 2.83, mescaline = 0.00
LSD: -5ht6 = 3.75, DMT: = 3.35, psilocin = 2.82, mescaline = 0.00
LSD: -5ht7 = 3.77, DMT: = 4.00, psilocin = 2.82, mescaline = 0.00
LSD: ---D1 = 2.34, DMT: = 3.51, psilocin = 3.37, mescaline = 0.00
LSD: -A-2A = 2.93, DMT: = 2.75, psilocin = 1.36, mescaline = 2.92
LSD: -A-2B = 0.00, DMT: = 3.53, psilocin = 1.57, mescaline = 0.00
LSD: -A-2C = 0.00, DMT: = 3.53, psilocin = 1.03, mescaline = 4.00

DMT: 4.00 5ht7, 3.97 5ht1d, 3.91 5ht2b, 3.53 Alpha2B, 3.53 Alpha2C, 3.51 D1, 3.42 5ht2c, 3.28 5ht1e, 3.25 5ht6, 3.16 5ht5a, 3.13 Imidazoline1, 2.95 Alpha1B, 2.75 Alpha2A, 2.70 Alpha1A, 2.58 5ht2a, 2.37 SERT, 2.23 Sigma1; 0.00: 5ht1a, D4, D5, Beta1, D2, D3, DAT, NET, 5ht1b, Beta2, Sigma2, CB2, KOR, Ca+Channel, M1, M2, M3, M4, M5, H2, CB1; ND: H1, DOR, MOR, NMDA

LSD: 4.00 5ht1b, 3.77 5ht7, 3.75 5ht6, 3.73 5ht1a, 3.70 5ht1d, 3.64 5ht5a, 3.54 5ht2a, 3.16 D3, 3.11 5ht2b, 3.11 5ht2c, 2.93 Alpha2A, 2.62 5ht1e, 2.55 D2, 2.39 D4, 2.34 D1, 2.05 D5, 1.54 Alpha1A, 1.40 H1, 1.39 Beta1, 1.05 Beta2, 0.65 Alpha1B; 0.00: KOR, DOR, DAT, SERT, MOR, NET; ND: Sigma2, Alpha2B, Alpha2C, Imidazoline1, M1, M2, M3, M4, M5, Sigma1, H2, CB2, CB1, Ca+Channel, NMDA

Psilocin: 4.00 5ht2b, 3.40 5ht1d, 3.37 D1, 3.03 5ht1e, 2.88 5ht1a, 2.83 5ht5a, 2.82 5ht7, 2.82 5ht6, 2.67 D3, 2.52 5ht2c, 2.19 5ht1b, 2.14 5ht2a, 1.77 Imidazoline1, 1.74 SERT, 1.57 Alpha2B, 1.36 Alpha2A, 1.03 Alpha2C; 0.00: D2, Alpha1B, D5, D4, Beta2, Beta1, DAT, NET, Alpha1A, Sigma1, Sigma2, DOR, KOR, MOR, M1, M2, M3, M4, Ca+Channel, H1, H2, CB2, CB1; ND: M5, NMDA

Mescaline: 4.00 Alpha2C, 3.97 5ht2b, 3.61 5ht1a, 3.44 Imidazoline1, 3.16 5ht1e, 2.92 Alpha2A; 0.00: 5ht2a, 5ht2c, 5ht6, 5ht1d, D1, D2, D3, D4, D5, Alpha1A, Alpha1B, 5ht5a, Alpha2B, 5ht7, Beta1, Beta2, SERT, DAT, NET, 5ht1b, Sigma1, Sigma2, DOR, KOR, MOR, M1, M2, M3, M4, M5, H1, H2, CB2, CB1, Ca+Channel, NMDA

I think it's funny that I have no experience with any maoi or harmala alkaloid but I have always had a strong intuitive feeling that rue was missing something...

We were surprised to find a significant up-regulation in the density of the citalopram binding sites in the hoasca drinkers compared to control subjects. Also, none of our subjects showed any evidence of any neurological or psychiatric deficit, In fact, in view of their exceptionally healthy psychological profiles, one of the investigators speculated that perhaps the serotonergic upregulation is associated, not simply with age, but with "wisdom"--a characteristic often found in the aged, and in many hoasca drinkers.

Suspecting that the causative agent of the unexpected upregulation might be tetrahydroharmine (THH), Dr. Callaway took SPECT scans of his own brain 5-HT uptake receptors prior to beginning a 6 week course of daily dosing with tetrahydroharmine, repeating the scan after the treatment period. He did indeed find that the density of central 5-HT receptors in the prefrontal cortex had increased; when he discontinued THH, their density gradually returned to previous levels over the course of several weeks. The implications are potentially significant.

magnesium (ribbon)... reducing agent to reduce harmaline to THH ... Somebody else said it wouldn't work since magnesium hydroxide isn't amphoteric

SWIM did a test. He wanted to see if THH could activate DMT by itself.

He mixed 200 mg of THH HCl with 20 mg of freebase DMT in 1 glass of water along with 100 mg of citric acid to make the DMT dissolve.

He drank it down. Effects started at about 10 minutes with a unusual tryptamine feeling. At 30 minutes the effects were just starting to get really intense. It peaked at about 45 minutes. At 1 hour it was definitely fading but not quickly.

During the peak, the psychedelic state was quite intense. There were DMT visuals as expected. The DMT overwhelmed the feeling of the THH. Even during the peak when the psychedelic effects are almost unmanageable, the mind still remained very clear and focused. SWIM was able to visualize people at will. It was quite remarkable. To give you an idea of the intensity, during the peak, closing the eyes lead to out of body experiences complete with other entities present. It was amazing. There was a very intense rush of energy during the peak. SWIM could not sit still and had to dance it off, which was a lot of fun.

The experience was more crystal clear than that achieved using harmine or harmaline. There was absolutely no mental fog present. THH leaves your brain in top condition. That’s the main difference SWIM noticed. THH smoothes out the experience without muddying the waters at all. It was the best oral DMT experience SWIM ever had. There was no nausea, and it was more crystal clear than an acid trip.

SWIM was able to sleep about 2 hours after taking it and had lots of fantastic dreams.

The trip was quite intense and it seems like the THH used was excessive. I imagine probably 100 mg of THH HCl would work. Next time SWIM will try that.

So to activate 20 mg of DMT, 200 mg of tetrahydroharmine hydrochloride is very effective.

This begs an interesting question, if aluminum pots are altering the entheogenic nature of aya, what was aya like before aluminum pots were traded throughout the amazon? What did they even boil aya in before metal? Imported earthenware vessels from other tribes?
If not the aluminum, then the reducing agent must be added via the herbal materials or the water. Fresh Psychotria leaves have vitamin C. Banisteriopsis has tannins that can act as reducing agents. Both have other polyphenols. (Peganum harmala seeds have far less (if any) of all of these compounds, AFAIK)
One of these days I should dust off my beakers and reflux harmaline with gallic acid for 12 hours to test the tannin hypothesis.

As to how the THH altered the experience -> I find rue extract+DMT to be very similar to mushrooms I found the THH added to the rue+DMT to shift the experience to a state much closer to that provided by LSD. It was more clear, more energetic, more focused, and when confusion struck it was definitely more "acid-like".

I believe quite a lot, if one is referring to Jesus (the Son of God & greatest Shaman of all time) I am a Christian and Jesus said "Behold, the lilies of the field--they are more marvellous than the palace of David. Behold the Birds--the Lord in Heaven watches over them". He went to the money-handlers and learned men in the temple and said "Go into your chamber and into direct contact with God." Only an individual person can have direct contact with God, not a church. Only an individual can see, can experience, has a consciouness that can conjure up the world that we see. Even this contact with God comes through our consciouness-and that is why scientific investigation of consciouness is so important. We are still at the very beginning, and LSD is the most important means for that, a tool--but as I said, we are just at the beginning of consciouness-research. It is my fond hope that this will advance, because we need a new type of Eleusis, lest our world be destroyed.