My girlfriend is looking into her first DMT experience and we are looking into safe methods to ingest DMT but she has epilepsy and is currently taking:

levetiracetam 3000mg, omeprazole 20mg, lamotrigine 200mg, co-codamol 500mg (as required), and tolterodine 2mg and naproxen 1000mg a day

I have no idea if there are ssri's or anything else thats contraindicated to MAOI's or if she should take DMT at all, her epilepsy is under control and we were hoping ideally Changa or Enhanced Leaf are a possibility, we understand ayahuasca may be out (ironically this would have been her prefered method) we are prepared for a comprehensive "NO she shouldn't have ANY form of DMT"

but any help with this, ideally by a medical professional that would give honest answers and not scaremonger as we believe our local doctors surgery may do would be most gratefully received.

Thank you all for any help.

There's only one person on this forum that has the right to say anything other than no she shouldn't taken any form of dmt in this situation. That would be corpus.

I'm not familiar with those medications. My vote is the risk is not worth any perceived benefit.

thanks anrchy, thats a shame i was hoping that changa or enhanced leaf would be ok.

Agreed with anarchy here on that matter. Its too dangerous to take dmt+5more drugs at once. It may cause permanent damage to her thinking or worse...
Im not at all worthy to give advice on the matter. Lemme see if I can pm a moderator with the skills so you can be informed.

Best of Luck! --dls--

thank you darklordsson (great name too) that would be great, I know she wants to try but we won't if its definitely advised against, we are just looking for any answers that might help find a definite yes "x method is ok" or a "no way".

Of course a straight answer is the best answer. Thanks, I thought it would be a cool screen name lol. But I sent him the message, he will get to you hopefully about this issue soon. I heard maoi's were the problem but like I said, I just don't have the knowledge to give, sorry my friend.

Best wishes and Good Luck!

The issues I see are as follows:

1.The pharmacodynamics of smoked or vaporised harmala alkaloids is not something that's properly established with any degree of certainty; there's experiential data ie trip reports etc but when it comes to assessing the risks/hazards with multiple medications (especially psychotropics/anti-convulsants) this needs to be borne in mind.

2.The dose of keppra (levetiracetam) cited above is at the top of recommended doses and this compound is fairly enigmatic insofar as its mode of action is not fully known. This makes it very hard to give a yes/no answer to the OPs query.

3. Tolterodines data sheet cites possible altered pharmacodynamics when used with CYP 3A4 and D6- interacting agents, of which include oral harmalas, but see point 1. re changa.

4.Epilepsy is a broad term which encompasses many 'conditions' which have recurrent seizures as one (but not necessarily the only) feature; without knowing a lot more about the case in question ie aetiology, syndrome etc it would be reckless to say 'do it/don't do it' because these issues can also impact on the risks of using centrally acting agents such as DMT.

I hope this is not seen as a cop-out but if I was on the above combo I would know that I would be venturing into very uncertain territory by using changa.

I feel I must state the obvious to offer some sort of positive answer to the op.

I cannot safely make any speculations other than this -

MAOIs are not needed to enjoy freebase DMT if vaporized.

Obviously the matter of safety still requires your attention, but removing the inhibitor, I would think, must reduce potential negative synergistic effects by a factor.

My point is - if you're gonna look into dmt for her - it might be easier to just look at vaporizing dmt freebase than any other admin method which includes harmalas.

Thanks guys, I realise a simple yes or no may not be possible due to the complex nature of the problem and and just how difficult it is to make a decision because of how individual the issue is, its exactly because its so difficult that I needed your help which I am thankful for.

I think for now we will not go ahead with DMT for her, or maybe as Adjhart mentioned just try very low dose freebase and then build up the amount of freebase vaped.

if ( and this is mostly academic but good for information) if she did want to do aya for example and came off her meds (again definitely NOT recommended) is there a period of time off her meds that would then be safe to take MAOI's in the form of aya for example?

would a period of say 6-7 weeks off meds put her in the clear to try it?

again we are prepared for (what seems the safest answer) either just dont do it at all, or as mentioned try low dose freebase and just be careful and extremely vigilant if we do decide to vape freebase.

Also a massive thank you to corpus callosum for the effort put into giving the best possible answer, none of that was a cop out answer because we do understand just how complex and difficult an issue it is, but we are extremely grateful for your answer and the time spent helping us make as informed a decision as possible in a totally unbiased way, which is exactly what we need.

I suppose another important question *might* be: has she any history with other psychs?

What about psilocybin? Once, twice, never?

How about since she started taking the medication?

I'm not saying the two are alike or anything like that, but I believe they are very similar in structure (no harmalas etc)

She's never taken any non prescription drugs before, hopefully mushrooms are an option or mescaline but I think ayahuasca was her preferred (and least likely) method of consciousness expansion. So we are trying to find if there's any safe way for her to explore.

would Salvia be safe for her perhaps?

in this situation

Harmaline/Ayahuasca, safe physically, dont know, perhaps also ask on the ayahuasca com forum?

DMT safe physically in a safe enviroment, yes

DMT "safe" psychologically, weeelll, its not to be fully honest, it is a tad bit strong..


From my own experiences with Benzos and DMT i can say that it limits ones range of experience and is therefore not worth it.

In any case, find out more about it before you "experiment"

Also, i assume its better to use DMT then Mushrooms in my opinion, solely because of the fact that if its a difficult experience it wont last as long as mushrooms.

I cant say

I would definitely NOT try Salvia

With regards to mush, it wasnt a suggestion, rather a question of prior experience.

In regards to duration, yes Bindu is right. But you can also start extremely low, then again you can do the same for spice.

I dont think anybody will be able to answer what kind of levels are safe... to be safe I would not even suggest cannabis, seeing as no prior experience...

sorry

be safe...

Because I am limited to where I can post I will put this here, there's nothing revelatory here but it is pleasing to me that this work is being legally and correctly explored

http://www.newscientist.com/art...-state.html#.U7pURBlwbqA