I cannot say that I've experienced full-on orgasmic sensations with entheogens, but mushrooms comes close to any psychoactive I've tried. The initial feeling with mushrooms is of pure, awe, divine energy that can become orgasmic.
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The mindset needed is of just being aware and communicative towards who and what you are.
Ego-dissolution involves not attaching to ego and allowing your being to empty.
Reaching a level where ego is non-existent is very powerful. Similar to what death would feel like(N,N-DMT specifically). Though, not necessary. Ego is fine once you stop encouraging it and, with all your heart, detach from it.
I don't think the ego can truly die as it is an important factor in determining survival. Though, ego is completely transcendent.
The higher the dosage, the closer you'll be to whatever it is you seek.
My first experience with mushroom changed my life. Mostly on the subtle level but also quite significant in itself. My perception, attitude, mood, dreams, well-being, personality, inner self, universal potential, so on so forth, have improved on many different levels, permanently. A positive shift so to speak.
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'What's going to happen?' 'Something wonderful.'
Skip the manual, now, where's the master switch?
We are interstellar stardust, the re-dox co-factors of existence. Serve the sacred laws of the universe before your time comes to an end. Oh yes, you shall be rewarded.