I got to thinking about this earlier some how. Not necessarily in the case of DMT, but for other substances where there's a MUCH longer duration like Psilocybin, or LSD or Mescaline.

Is there any sort of drink that can be consumed (or anything, not necessarily just a drink) that would either cancel out the effects of the drug or at least inhibit further effects?

I feel like logically there should be SOMETHING (though there doesnt seem to be ) that could either break the bond between receptors and the chemicals or at least block further binding between receptors and the active chemicals if one wished to end a (bad) trip early.

Benzo's work particularly well for aborting a trip. Xanax, Valium, etc.

Sure benzo's could be used but...

Buy the ticket, take the ride.

In my experience the bad ones can turn out to be the best ones

For LSD:

Laurence Brunton , Bruce A. Chabner, Bjorn Knollman: Goodman and Gilman's Manual of Pharmacology and Therapeutics Twelfth edition

There are way better ways of dealing with rough trips than simply trying to abort. A lot can be learned from them too. I'm glad I had mine.

Benzodaizapines won't abort the trip, they will just calm you down and alleviate any anxiety.
They do reduce the intensity to some degree, but they won't stop the trip.

If you want to fully terminate a psychedelic experience, you need a 5-HT2A receptor antagonist that will act in direct opposition to the psychedelic agonist.
This class of molecules are known as atypical antipsychotics and they are pretty potent drugs. They're what people who suffer from schizophrenia and other forms of psychosis are prescribed.

Risperdone, Seroquel and Zyprexa and the most common ones. Seroquel is occasionally prescribed off-label from the treatment of insomnia, so it will knock you out, in addition to ending the trip.

As Anrchy said, pharmacologically aborting a trip really should be a last-resort kind of thing though. Stanislav Grof had a lot to say on that topic.

Blessings
~ND

Not to mention the difficulty in obtaining, and dangers of routine use of benzos.
Quite easy to abuse that critter, and quite hard to quit.

I remember a recentish clinical paper [1] that found lavender oil capsules to relieve anxiety as well as the high strength benzodaizapine lorazepam. Reading that I was reminded of other papers in which the smell of lavender alone was proven anti-anxiety and of a mate of mine who would add lavender to half of his changa mixes to keep people calm.

Thanks for all of the answers folks, and Nathanial kudos for going heavy on the science side. I always enjoy super specifics Very interesting on the lavender too.

Totally agree with you all on the avoid aborting thing, I meant to mention that part when I posted but I had forgotten to add it in haha. I was just curious if it was possible at all! I have zero experience with any other substances and dont really see myself venturing out that way as of now.



In addition to what Nathanial said, I find it rather fascinating that a pharma drug which could cancel out the psychedelic experience is ALSO a drug used for treating schizophrenia.

It truly says a lot about schizophrenia treatment and how poorly understood schizophrenia itself is. Very very fascinating. Thank you for sharing those intricate details.

You know if you tried a gram of reg cubensis's the trip would be very manageable and allow you to observe the effects without worry of a bad trip or going very far.

A gram can be a very calm and enjoyable light trip.

I'm not sure I completely agree with this statement. I have found that low doses of psychedelics leave me in this weird pseudo-psychedelic limbo that I find much less comfortable and enjoyable than what I would experience from a full dose. I've never thought the effects from a small dose of a psychedelic really give a person much of an idea of what a full dose would feel like. I think that one of the many ways that psychedelics differ from other psychoactive substances is that one can't exactly "test the waters", so to speak.

But I can only speak of my own experience, perhaps that isn't the case for others.

Propanolol hydrochloride can numb a trip and take away any mania but wont abort a trip completely, I doubt it would work with high doses and especially not with something like ayahuasca, it could well be dangerous.

Forced positive thought has worked with me to turn a bad trip around on LSD before, similar I suppose to being talked down. You just have to give it time to work.

Please do a search.

Trip Abortion Thread

Aborting A Trip / Benzos

much love,
tat

Interesting paper. I bought some - let's see, if they can abort a green tea trip Sometimes the heart pounding gets out of hand and is really annoying.

Getting these meds in an urgent situation may not always be very easy...

If it's lsd we're talking about, then columbian dancing dust has been known to very effectively re-direct or even terminate an lsd experience...

For me personally, caffeine also seems to have a very detrimental effect on lsd trips which is way I stay away from it when tripping
Too bad they never make irish coffees with decaffeinated coffee...

Word of particular caution regarding using antipsychotics to abort a trip…

antidopaminergics (haldol/risperdal, etc) have a slew of very nasty side effects, for some people present from a single or very few doses. The literature is fuzzy regarding how often or much you have to take to develop some of these terrible conditions (extrapyramidal symptoms/tardive dyskinesia/dystonia, etc) though I have experience administering single doses of IV Haloperidol and patients developing permanent motor/tic dysfunctions.

Benzos are less dangerous by far (in appropriate doses), though I strongly agree with non-pharmacological management of bad trips.

Changing environment often works for me when things get squirrelly. Sometimes as simple as walking outside or changing music can have a profound effect.

I second this.

As long as it's not aborts.

Aborts pack a wallop ime so far.