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Posts: 5257 Joined: 29-Jul-2009 Last visit: 24-Aug-2024 Location: 🌊
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Al Dimentiz wrote:To treat somebody for depression using mushrooms.... What dosage would you recommend? And why?
Would you recommend a 5 grams breakthru dose and let the elves do the talking? Or, a small dose 1.5, 3 grams?
I'm asking this bc my wife has an aunt with severe depression and she wants to help her. (Her Aunt has never taking psychedelics before)
And my wife says that taking 5 grams is a lot easier and more effective than taking a small dose. (With smaller dosages all she gets is anxiety)
Its really hard to say what the best dose would be, and it can depend on a number of things...but 5g sounds too high in this case. Make sure her aunt does a lot of research and knows what she's getting herself into. You have to be VERY aware of both her mindset is unfolding in the days and hours before the experience, and the environment she'll be taking it in, if you want to maximize the benefits and reduce the risks of things going south Has your wife ever tried taking smaller doses in a safe and secluded nature setting? Lower doses are so much better that way for me.
<Ringworm>hehehe, it's all fun and games till someone loses an "I"
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 DMT-Nexus member
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Posts: 4804 Joined: 08-Dec-2008 Last visit: 18-Aug-2023 Location: UK
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Psilocybe ayahuasca, hands down.
I do get this effect using a DMT admixture also, but nothing was ever more sustained to near permanence like with the mushroom. With something like MXE, I'd feel content like I was still on something for the 7 days following the experience. Psilohuasca seemed to allow me a place to work out my problems and provided me with the inspiration to solve them. Didn't take much either. I'd say the dose required is just over threshold and in a way less 'scarey' than a dissociative.
That said though I have great trust in that combination and maybe the average everyman wouldn't find it so gentle.
I guess Psilohuasca inspired change in me and MXE made me want MXE again a week later.
Your milage may vary.
Not as well versed in it but I think salvia has a similar Anti-depressant effect to MXE with less long term risk, though the initial experience is... an acquired taste.
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 DMT-Nexus member
Posts: 1817 Joined: 22-Jan-2009 Last visit: 04-Aug-2020 Location: Riding the Aurora Borealis
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soulfood wrote:Psilocybe ayahuasca, hands down.
Not as well versed in it but I think salvia has a similar Anti-depressant effect to MXE with less long term risk, though the initial experience is... an acquired taste. This has been something very healing for me as well, psilohuasca. There's something really motherly about that whole experience, every time I've done it. The afterglow from a good session has lasted almost two weeks for me in the past. Also, Salvia has healed me from severe depression. It completely changed my thought patterns and I no longer get crippling bouts of depression. If I feel down and out, and it lasts for more than a day, one hit of Salvia leaf turns it around. Breakthrough doses aren't required at all for me to get extreme positive mood lifts. All the talk about dissociatives applies to Salvia as well I think. It's dissociative, but also psychedelic. More balanced than something like ketamine. And definitely its polar opposite where addictive behavior is concerned. Salvia is something you have to force yourself to do most of the time, like ayahuasca in a way. An acquired taste for sure  In my past I went to cannabis over and over to treat my depression. It worked at first, but after years it actually made it more crushing and debilitating. I abused it, of course, but I don't really feel it's a good treatment for depression. At least not in my case. Psilocybin, DMT, and Salvia are far better for lasting change.
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 DMT-Nexus member
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Posts: 12340 Joined: 12-Nov-2008 Last visit: 02-Apr-2023 Location: pacific
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I need to try mushrooms with rue and caapi again. I only tried it once, with about .2g of mushrooms cus my mimosa never hit it was still strong. Another time I ate one little abort about 3 hours after drinking ayahuasca, as the ayahuasca was wearing off and it hit me nice also but only seemed to last 1.5 hours tops. I must say it is a combination that has always freaked me out to think about because of how strong mushrooms can be and how long they can keep you there already without adding harmalas. I really want to explore it though. Long live the unwoke.
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 DMT-Nexus member
Posts: 1075 Joined: 01-Sep-2010 Last visit: 12-Aug-2019 Location: Out here
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jamie wrote:I need to try mushrooms with rue and caapi again. I only tried it once, with about .2g of mushrooms cus my mimosa never hit it was still strong. Another time I ate one little abort about 3 hours after drinking ayahuasca, as the ayahuasca was wearing off and it hit me nice also but only seemed to last 1.5 hours tops.
I must say it is a combination that has always freaked me out to think about because of how strong mushrooms can be and how long they can keep you there already without adding harmalas. I really want to explore it though. That do sound quite intense jamie, ive never combined all three but rue/caapi and shrooms plenty of times. I really prefer it to just shrooms, at least if im looking for a more intro kind of trip. Harmalas really seem to work as a translator of some sort and the mushrooms message becomes very clear to me in combination. Also though i would not recomend it to anyone but ketamine is a very efficient anti depressent agent since it seems to just shut down everything that seems to be going on in your mind during the hole. This puts you in totally meditative state where you can really feel whatever is going on within all the layers of defences that usually blocks your thoughts. Its almost like a defragmentation of some sort, esp if combined with a psychedelic. But beware k is very addictive and if one would like to try it for depression i recomend no more than 500mg in one evening and then stay away for at least a couple months.
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 Astro-Travellin
Posts: 400 Joined: 09-Aug-2012 Last visit: 12-Nov-2018 Location: Entangled with you
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I wish i could locate some good K. I could definitely use its therepeutic action right now. I might have to try out the harmala's. Is that only recommended for extracted harmalas or can ground rue in capsules be used? I have very little experience with harmalas and i have yet to extract them. Wondering if there would be any of the same benefit with the ground rue. Coinci-Transcendentalism
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 yes
Posts: 1808 Joined: 29-Jan-2010 Last visit: 30-Dec-2023 Location: in the universe
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listening to music can also heal depression ( just dont listen to depressing music ) also microdosing psychedelics might be a good idea illusions !, there are no illusions there is only that which is the truth
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 analytical chemist
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Posts: 7463 Joined: 21-May-2008 Last visit: 14-Jan-2025 Location: the lab
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Jin wrote:listening to music can also heal depression + ∞"Nothing is true, everything is permitted." ~ hassan i sabbah "Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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 DMT-Nexus member
Posts: 1856 Joined: 07-Sep-2012 Last visit: 12-Jan-2022
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Jin wrote: just dont listen to depressing music I quite like listening to depressing music when i"m depressed. It always makes me think there is someone more worse off than me. Or atleast in the same boat. You can wallow in self pity in the company of your musical heroes.
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 DMT-Nexus member
Posts: 343 Joined: 29-Jan-2012 Last visit: 15-Jul-2017 Location: everywhere
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Yeah, when you are already at the absolute bottom, why not take some shrooms and listen to the most depressing music. Often one part of the depression is the attachment/repulsion to ones own suffering and sadness. Let the power of the music vibrate through your body/soul/mind and purge out hrough the tearducts. This piece of music here works exceptionally well on me. http://www.youtube.com/watch?v=izQsgE0L450Those high tones of the strings cut through my defense like a katana through butter.
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 DMT-Nexus member
Posts: 2151 Joined: 23-Nov-2012 Last visit: 07-Mar-2017
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MomentOfTruth wrote:I wish i could locate some good K. I could definitely use its therepeutic action right now.
I might have to try out the harmala's. Is that only recommended for extracted harmalas or can ground rue in capsules be used? I have very little experience with harmalas and i have yet to extract them. Wondering if there would be any of the same benefit with the ground rue. Be careful of self-medicating with Ketamine. I know it has powerful antidepressant properties, but it's also addictive and does TERRIBLE things to your kidneys/excretory system with long term abuse. If you can make it work, more power to you, but I for one don't want to risk it. I also got a bit too into ketamine at one point in my life, so I may be a little biased. Blessings ~ND "There are many paths up the same mountain."
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 ღஐ~Ƹ̵̡Ӝ̵̨̄Ʒ~ஐღ
Posts: 281 Joined: 28-Dec-2009 Last visit: 08-Mar-2020 Location: 45th parallel
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Drugs-the party type will magnify your depression, stay away from them at all cost! None of them will work for you long term-NONE! Try St Johns wart, 5HTTP or S-Adenosinemethionine but to be honest these things did very little for me. Find what you love, what makes you jump out of bed in the morning or stay up late, what makes you smile-something you can do yourself without any outside influence and do it over and over. Call everyone you know-even just to say hi(this helps a lot). Talk to strangers-do small acts of kindness for someone else. Write a love note. Find whatever "switch" works for you to change your mood. "depression is like standing in a pitch black room and not feeling around for the light switch" Feel around, fall over, look like a fool-whatever it takes, just find that switch. Perhaps I am asking the wrong questions but it doesn't interest me who you know or how you came to be here. I want to know if you will stand in the center of the fire with me and not shrink back.
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 DMT-Nexus member
Posts: 3207 Joined: 19-Jul-2011 Last visit: 02-Jan-2023
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Al Dimentiz wrote:To treat somebody for depression using mushrooms.... What dosage would you recommend? And why? http://www.newser.com/story/121...for-medical-shrooms.htmli would try to find the John Hopkins study behind that article, and work from there. EDIT: gizmag wrote:Perhaps unsurprisingly, researchers noted that the reported positive effects increased as higher doses were given, but also that there was a sharp increase in the negative aspects at the very highest dose. At the highest dose (30 mg/70 kg, p.o. - meaning "per oral" or by mouth), 78 percent of the volunteers were reporting one of the top five most spiritually significant happenings of their lives but those suffering anxiety, stress and fear episodes increased by six times, so that around a third of those participating in the study showed signs of psychological struggle.
By contrast, only one of the volunteers receiving the second highest dose (20mg/70 kg, p.o.) reported having negative issues, and all benefited from positive experiences, although with less intensity than at the highest dose. Critically, even the lowest amount used in the study resulted in notable and long-lasting positive changes in the attitudes, behavior, overall satisfaction and spiritual beliefs of the subjects during the period of study. These changes were also noticed by family members and friends. and: http://csp.org/psilocybin/PressRelease201106.pdfMy wind instrument is the bong CHANGA IN THE BONGA! 樹
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 Cloud Whisperer
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Dio I have personally found through my own experience that low infrequent doses of crystal MDMA does wonders for mood enhancement and upliftment. Though it is of great importance to make sure that the MDMA is as pure as possible, as some MDMA can be contaminated with aluminum and mercury. Green tea, reishi mushrooms, withania somnifera, ginkgo biloba, cacao beans, low doses of mushrooms and cactus are all incredibly powerful in remedying symptoms of depression. Going out for a hike and reconnecting with nature and spending some time outdoors in the sunshine will go a long way into making you feel as right as rain again. Its all about creating balance within your life, making sure you eat a healthy diet that includes dark green vegetables, fruit, berries, nuts and if you enjoy fish do your best to eat oily fish which are rich in Omega-3 fatty acids. I wish you the best of luck and please keep us up to date on your progress... Much Peace and Happiness
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Posts: 4804 Joined: 08-Dec-2008 Last visit: 18-Aug-2023 Location: UK
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Pharmer wrote: Call everyone you know-even just to say hi(this helps a lot). Talk to strangers-do small acts of kindness for someone else. Write a love note. Find whatever "switch" works for you to change your mood. "depression is like standing in a pitch black room and not feeling around for the light switch" Feel around, fall over, look like a fool-whatever it takes, just find that switch.
Thank you for that.  That makes so much sense. Just got to get the do's going on.
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