Hi guys,
SWIM wanted to explore a bit the chemistry of Salvia in order to respectfully increase his knowledge and play a bit with the ROAs. Still, he hasn't found much about the solubility of Salvia, beside the Naphta-np solvents-water insolubility (or very very low solubility) and the high acetone solubility. In saliva also should dissolve, doesn't it? And then what?
What about, I don't know, milk, oil, DMSO? Has someone tried some unusual solvents and know something about it?


Thanks to everyone who wishes to contribute, SWIM will eventually post the result of his experiments.

well seeing as how it is soluble in acetone (polar solvent), and insoluble in NP; i would guess that anything polar (except water, apparently) is the way to go.

Alcohols suck more moisture out of the air and so an extract takes much longer to dry. Acetone does the same but seems to dry quicker. Sure you might be able to other materials but how will you dry the extract ? Or are you looking to make a tincture?

I wonder how quidding even works if salvinorin A is hardly soluble or insoluble in water.

We know salvinorin A is a hydrophobic diterpene, so if other known diterpenes like the phyto-cannabinoids are soluble in lipids, alcohols but barely in water, it would not be surprising that salvinorin could be also extracted using for instance vegetable oils. The oral activity of the extract, though, is another story.



Most likely a compound present in the leaf complexes with salvinorin when quidding and highly improves absorption through the oral mucosa. We might think it has to do with saliva composition, but in that case a simple ethanol tincture would work the same, and it does not.

Thanks everyone for replying,
my interest would be trying the rectal ROA, so I'd need an harmless and effective solvent. If it is soluble in polar solvents and alcohols it should work well with glycerol, doesn't it?
Maybe doing a cold acetone wash and than, when almost dry, add glycerol and wait for the acetone to evap can work nice. I've read the report of a user here using saliva, but I'm sure there are better and easier way.

Glycerol (glycerin) has been used successfully in THC extracts, so it might work well for salvinorins.

As for the rectal ROA, I bet it will work well as long as the enzymes responsible for the degradation of salvinorin in the human body are not particularly abundant in the rectal tissue, when compared to the gut. Those seem to be carboxylesterases and lactonases. Do not miss this thread by Infundibulum about salvinorin metabolism.

Hi guys, a little update.
I've tried using glycerol. I've done 4 cold acetone washes of 2 minutes each, let it dry and then added glycerol, 2 ml. Don't know if salvinorin is completely soluble but it turn to a greenish color pretty fast and seemed like nothing was left in the cup.

I then took a syring and plugged the glycerol -BUT- maybe my methabolism is too fast, or something else, but the laxative effects of glycerol started to kick very strong after as little as 30 seconds, and I couldn't hold it. Fortunatly, knowing that this could happen, I tried it in the bathroom, so I just had to make one step to release everything.

I enjoyed the laxative effects of glycerol, less traumatic than a water enema and yet very effective in cleaning my intestine, but the experiment was a failure from the drug prospective.
I'll try other solvents and let you know.

Ah, thanks Vodsel for the link, I missed that topic, Very interesting indeed!