First time:

T+0min - Took 250mg harmala alkaloids (HCl salt) in capsules
T+10min - Took 300mg DMT fumarate salt in capsules

SWIM felt the mixed harmala alkaloids, but not the DMT. Very little if any tryptamine hallucinations and no purge.


Second time:

T+0min - Took 300mg harmala alkaloids (HCl salt) dissolved in grapefruit juice
T+35min - Took 350mg DMT fumarate salt dissolved in grapefruit juice

SWIM felt... wow... words cannot explain. Violent purge followed by vivid hallucinations similar to vaporized freebase. Wow, what a difference.




So what happened the first time is the DMT must have been broken down by MAO before the harmala alkaloids had the chance to inhibit.

The second time the DMT was taken after the MAO had been inhibited, and wow is all I can say about the effects of that.

Lasted a good 8 hours.

As a side question... isn't traditional ayahuasca taken mixed, with caapi and viridis together in one drink?

I would hazard a guess that most of what SWIM would feel using that preparation method would be the harmala alkaloids. That is probably why the shamans consider the vine to be the most important ingredient, because that is what you are feeling.

SWIM has always found that a bit odd how little DMT the traditional preparations contain.

It’s not normal for traditional ayahuasca used by Native South Americans in ritual to be taken in a single dose. Consider that when basing doses on traditional ayahuasca.

Traditional ayahuasca is normally taken in two or more doses spaced apart about 20 minutes or more from each other. The amount of alkaloids present is low because people are expected to take 2 or 3 doses spaced out.

If you use capsules, you need to wait 35-45 mins between taking the maoi and the dmt. I waited 20 mins between once and 300mg of spice didn't work on me either.

Oh my, what a massive dose you need.

Recently I took a pharmahuasca journey:

T+00:00 - Took 90mg of harmala alkaloids, extracted from rue in capsule together with water
T+00:40 - Took 90mg of DMT in capsule together with water
T+01:40 - Journey finally kicked in
T+02:00 - Peaking starts
T+02:30 - Comming down
T+03:40 - End of journey, only trace amounts left

This was my first journey with extracted harmala alkaloids. It took a real long time for the DMT to kick in and I even thought a failed harmala extraction was the cause. The relatively low dose of harmala was done by purpose to shorten the journey, also too much harmala gets me stuck in a loop way too often.

In retrospecs, the journey from entering hyperspace to landing was 2 hours, it took one hour and forty minutes before reaching hyperspace, a real long time I must say. Maybe this prolonged launch time was caused by me eating 2 hours before taking the harmala pil. I have to say that this prolonged launch time smoothed out the experience and while it was an intense ride it was also very much controllable.

With 200 mg of hamine or THH taken orally, SWIM can get a visionary level experience from just 20 mg of DMT taken orally AT THE SAME TAME as the MAOI. DMT oral dosage varies a lot from person to person.

That is very interesting.

For SWIM it seems that he has really a lot of MAO or something, and if the two are taken at the same time SWIM's body is able to break it down before the MAOI has had a chance to have an effect.

That is probably why such a large amount is needed in his case.

Vaporized freebase the effective dose is normal, around 30-50mg.

For SWIM there's very little difference between the oral dose of DMT with MAOI and the smoked dose of DMT without MAOI. Either way, 20 mg is a visionary dose. 50 mg is a near breakthrough dose. At 10 mg he feels it and there are mild visual effects.