Hey all. In recent days, a friend helped the spice found me to the tune of 500mg fumurate. I obtained a 10x b. caapi extract in leu of doing it myself. I do not have the proper space for extractions at this point. I have a couple questions regarding this information. The b. caapi contains about 500mg of alkaloids in the bottle. I unfortunately do not know the ratio of Harmine to Harmaline and THH but I think, if I remember correctly, B. caapi is predominantly harmaline.

1. What is a proper dose for the first time? I was thinking around 80-100mg spice and 150mg of the caapi extract?
2. Will this make me nauseous?
3. Does weight play a factor in MAOI inhibition. I guess I want to know, does it take such and such an amount for MAOI inhibition across the board, or do tolerances and weights play a factor. My wife is highly sensitive to things like lsd and mushrooms and I want to make sure I do not go overboard for her. (she usually does half what I do)
4. My wife and I want to do it together, but for the first time we are thinking of taking turns. Is this a good idea or can we do something like this together the first time?
5. Is this something we should do at our home or would we be ok doing it outside? I feel like home is a good place to start for any new substance but I live in an apartment and am surrounded by other people.

Thanks so much for any information on this. We are truly lucky to have such a great community to turn to. I've been reading the forums for a while and have just decided to post. Thanks again for guiding the breakthroughs of many a curious individual.

I'm not sure if 150mg will necessarily be enough to provide oral inhibition. It would be enough to potentiate the effects of smoked DMT for sure. Like way more than needed to potentiate smoked DMT, but in the case of taking pharma (taking the DMT orally), I believe the rule of thumb is around 250mg harmalas. It's easy to have misfires with pharma, so I would ere on the 250mg side. 80-100mg of spice isn't entirely reckless, but everyone's sensitivities vary, and it's not too clear what the variables are. Weight doesn't necessarily seem to play a factor here. Everyone's digestion and metabolism are so different, that it's hard to tell 50mg may be too much for some, and others need 200mg to achieve the same effects. 80 is a moderate place to start.

Since you're taking extracted harmalas and DMT fumarate, it shouldn't make you nauseous, but there's always the possibility. If you become nauseous, try and keep it down for around an hour and then see if it's ready to come up. I like to get the purge out of the way early on at the 1 hour mark so I can enjoy the rest of the trip nausea free, and the purge can often get things really kicking in gear.

In terms of weight and MAO inhibition, it does seem to be a bit of a factor, but in this case 250mg is really sort of the lower limit, so you should both probably just split what you have of the harmalas. If you wanna give her less DMT, that might be a good idea. I'm particularly sensitive to LSD and mushrooms as well, and I don't need nearly the dose some people need for pharma.

Pharma is a rather long experience. It can be a very meaningful experience to share, but don't plan on moving around too much. You'll pretty much want to establish a nest for yourself wherever you do it where most of the things you'll need will be within arms reach, cause it can really immobilize you. If needed, you can get up, it just takes so much will power lol. My recommendation would be to do it at home. You want to be some place where you can be comfortable. It is not suited towards adventuring around as much as LSD or mushrooms. It can be quite sedating. You may also want to have music or a playlist established, blankets, a sweatshirt if needed to take on and off as your sense of temperature can alter rapidly.

If it's not kicking in as strong as you like. Don't give up hope! You can always smoke some DMT to really kick things into gear for a while. It tends to last 40 min - hour and when it's over, if you feel like you could use more, just take another hit or two, and you'll be up in the stratosphere for another bout. Exercise caution though because it really makes the DMT a lot stronger, so you may not need as much, and it takes a slight delay to kick in. Usually I can start to feel it and see it come on rather instantly as I'm holding in my hit, but when harmalas are in the mix, it seems to take an extra 15-30 seconds to kick in which can be deceiving if you decide you'll need an extra hit.

Thanks Global for your insight! I have enough to err a bit the first time so I guess it would be proper to start slowly. I think we will likely do it at home. And I will probably consumer half the bottle (250mg) and let my wife start with 150. We have another with 500mg for the next attempt. I am definitely not a plunger, I like to take the stairs.

Heh. I'm probably more the plunger type, but everyone needs to go at their own pace. Pharma is always an exciting venture, so you'll have to make sure to let us know how it goes or if there are any problems or further questions.

Hi,

I started journeying with Pharma quite recently, but I already learned something that works/doesn´t work for me:



I would suggest to adjust dosing according to your previous experiences with long and deep journeys. For me, taking 60mg of DMT orally would be something like 5 grams of dried Cubensis...



I don´t get nauseous, but I think it is a good idea to have a bucket next to one´s bed. Just in case



I personally prefer being alone. (Having a sober sitter on one´s first journey is also a good idea, I think. Especially if you plan eating 80-100 mgs). On a heavy Pharmahuasca journey, I am not able to move, and really not willing to actively communicate with other people.



I always do it at home, in my bedroom, which is a safe place for me. I also do it in silence and darkness. This setting helps a lot to get fully immersed into the experience, and to follow its inner "logic".

Personally, I would never consider journeying outdoors, because I know couldn´t be truly alone, in a complete silence, and darkness... 80-100mg would completely immobilize me for something like 3 hours (I weight around 180 pounds).

Safe journey, and let us know how it went.

Hmm thanks for the input Michal. Sounds like maybe I should start a bit lighter than my 80-100 just to ease into it. I've eaten about 4.5g dried so maybe I should start a little slower. Maybe like 50 plus 200-250mg Alkaloids. I weigh right around 160 so I am a lighter person. I am thinking now I will try it first at that dose to see how it affects me then dose my wife accordingly.

Thanks so much for the great info guys. It's really helping me prepare and feel comfortable for my first journey.

I weigh 100lbs and take 250mg, so I think you should be good with that. I typically only take 50-70mg DMT, but an hour after ingestion, I always supplement with vaping DMT so I can quickly navigate straight to my sweet spot.