I haven't been able to uncover too much information regarding how the tolerance to caapi and other harmalas work. I have seen some people say it has a reverse tolerance.
Is that always the case?
Do you have to work with the vine often to achieve this?

I find the idea of reverse tolerances quite fascinating from a neurochemical but also a spiritual view. Why would our brain have such a reaction when, in most cases it's the exact opposite?

there is definitely a sort of reverse tolerance going on with frequent use..definitely no tolerance.

I'm not sure why but if you work with higher doses of the vine or rue you become more sensitive to it, while simultaneously you can handle higher amounts better

Oh man, thats very nice. Do you know of any tips or methods to go deeper into an experience?

lay down in silent darkness and relax, breathing deep and slow. 8hz binaural beats can be a nice addition as well, IME. And if your just taking the harmalas don't be afraid to dose higher than you usually would. visionary doses of caapi/rue alone are typically very warm, friendly, and easy to handle when taken this way..

Once you add in some admixture plant/dmt though it can change dramatically. Both are great to explore and i find it best to add in smaller amounts of mimosa on top of a higher dose of caapi/rue

I have never experienced tolerance even with daily use for extended periods.

Strange though Dagger has claimed to experience tolerance to the visionary effects of harmalas. This is the only claim I have ever heard of this happening though.

I know that for me I just am able to tune into it more and more the more I take them.