Not I
Posts: 2007 Joined: 30-Aug-2010 Last visit: 23-Sep-2019
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benzyme wrote:Quote:If 5-methoxy is produced in the pineal then it would seem pretty obvious the DMT would be as well. This is a very old paper though...so I want to see what it say's before jumping to conclusions.
I probably can't get this paper, but I could tell you the 5-MeO products are from 5-HOIMT; they put methyl groups on the 5-position oxygen, rather than the terminal amine. Where does the n-methylation come from though? We know it can o-methylate from the melatonin pathway. If your religion, faith, devotion, or self proclaimed spirituality is not directly leading to an increase in kindness, empathy, compassion and tolerance for others then you have been misled.
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analytical chemist
  
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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therein lies the mystery... maybe the spine? I've heard it mentioned that the path up to the pineal gland lacks the phospholipid bilayer (BBB) "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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Not I
Posts: 2007 Joined: 30-Aug-2010 Last visit: 23-Sep-2019
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neurochemistry rocks.  If your religion, faith, devotion, or self proclaimed spirituality is not directly leading to an increase in kindness, empathy, compassion and tolerance for others then you have been misled.
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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cheers to that. I know you have metaphysical theories as well, but you also seem to have an understanding of biochemical processes too; a reason we can have reasonable debates and sensible speculation. Obviously, subjective experiences are not debateable. I won't argue against the fact that people have NDEs, but I can point out that NDE's have been reproduced by mechanically induced hypoxia (ex. air force pilot training). how people interpret them, well, that's part of the mystery of the human mind. "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 56 Joined: 04-Feb-2012 Last visit: 30-Apr-2022
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Well i have found some new information on the pineal gland and DMT. I was watching the Science of death by Nat Geo and they showed that new information has arisen that in fact the Pineal gland does create/or regulate the DMT in the body. I also found this in my Psyche book as well. This book was written about a year ago so it is pretty up to date. I have made the PDF format in a link for you all to look into http://pdfebooksfreedown...-edition-in-modules.htmlNow i am not saying that what everyone said here is wrong. I read this entire thread and all views are rather interesting. I just thought i post something that perhaps would get some of you to do some more research into the matter.
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DMT-Nexus member
Posts: 14191 Joined: 19-Feb-2008 Last visit: 28-Nov-2024 Location: Jungle
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Im attaching the publication mentioned before: Biogenesis of 5-methoxy-N.N-dimethyltryptamine in human pineal gland Journal of Neurochemistry. 1976. Vol. 26. pp. 187-190 Btw for those that want to read more about this whole pineal thing, this is another long discussion we've had regarding pineal and dmt a while ago.
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⨀
Posts: 3830 Joined: 12-Feb-2009 Last visit: 08-Feb-2024
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psychedelicbuddha wrote:Well i have found some new information on the pineal gland and DMT. I was watching the Science of death by Nat Geo and they showed that new information has arisen that in fact the Pineal gland does create/or regulate the DMT in the body. I also found this in my Psyche book as well. This book was written about a year ago so it is pretty up to date. I have made the PDF format in a link for you all to look into http://pdfebooksfreedown...-edition-in-modules.htmlNow i am not saying that what everyone said here is wrong. I read this entire thread and all views are rather interesting. I just thought i post something that perhaps would get some of you to do some more research into the matter. Many of us have done a good deal of research on the issue. Do you think you can provide a link to a study showing what you claim? Specifically, that the pineal creates/regulates DMT in the mammalian body? "Facts do not cease to exist because they are ignored." -A.Huxley
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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yes, post refs. to be reviewed. we have. "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 332 Joined: 19-Jun-2010 Last visit: 16-Jan-2020
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a1pha wrote:psychedelicbuddha wrote:Well i have found some new information on the pineal gland and DMT. I was watching the Science of death by Nat Geo and they showed that new information has arisen that in fact the Pineal gland does create/or regulate the DMT in the body. I also found this in my Psyche book as well. This book was written about a year ago so it is pretty up to date. I have made the PDF format in a link for you all to look into http://pdfebooksfreedown...-edition-in-modules.htmlNow i am not saying that what everyone said here is wrong. I read this entire thread and all views are rather interesting. I just thought i post something that perhaps would get some of you to do some more research into the matter. Many of us have done a good deal of research on the issue. Do you think you can provide a link to a study showing what you claim? Specifically, that the pineal creates/regulates DMT in the mammalian body? benzyme wrote:yes, post refs. to be reviewed. we have. He's already posted a link to his source and he doesn't appear to be making the claim, just posting some interesting info he came across. So the question is does this book backup it's claims? What refs does the book give? And as for Nat Geo, they're not very creditable IMHO EDIT: OK, I can't download your book!! Whats up with that? Its the MeICNU
I am only someone's imaginary Smelf posting from hyperspace.
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Posts: 3830 Joined: 12-Feb-2009 Last visit: 08-Feb-2024
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^^^ He posted a link to his college psych book. Did you look at it? Doesn't provide much in the way of peer-reviewed research. "Facts do not cease to exist because they are ignored." -A.Huxley
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DMT-Nexus member
Posts: 332 Joined: 19-Jun-2010 Last visit: 16-Jan-2020
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a1pha wrote:^^^ He posted a link to his college psych book. Did you look at it? Doesn't provide much in the way of peer-reviewed research. I understand, but still the book is making the claim. Sounded to me that he just wanted to know what we thought of this. And no I didn't expect his college psych book to be very creditable either. Its the MeICNU
I am only someone's imaginary Smelf posting from hyperspace.
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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a psychology text is hardly a credible source for a neurochemistry theory. "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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member for the trees
 
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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^..as a psych, i agree..lol.. though i don't know if many neurologists can describe what it feels like to be alive...
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analytical chemist
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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neurologists deal more with the physiology of neurons than the chemistry, so that doesn't surprise me. "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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DMT-Nexus member
Posts: 14 Joined: 30-Aug-2008 Last visit: 21-Jul-2012
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If DMT is produced in the pineal gland and the gland is outside of the blood-brain barrier, does it not travel downstream instead of up?
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SeeingFacesInManyPlaces
Posts: 186 Joined: 24-Aug-2012 Last visit: 21-Mar-2019 Location: DancingBetweenPlanes
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Bump for interest.... anybody come across anything else on this subject? [center]Sophia's Light
In darkest night, when lights are dim, and all in sight seems sad and grim,
I find you there, your arms surround me, your spirit fills me and it grounds me.
I look to you, Lady of Truth, most ancient One, yet eternal youth,to keep me safe, protect my heart,and with the wisdom you impart, fill up my empty mind and soul,so that, my Lover, you can make whole, all that was broken in this day –and that is what I ask and pray.
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DMT-Nexus member
Posts: 2 Joined: 24-May-2013 Last visit: 15-Dec-2015
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Botanical Bliss wrote:Bump for interest.... anybody come across anything else on this subject? Interesting update from CRF today: CRF wrote:We’re excited to announce the acceptance for publication of a paper documenting the presence of DMT in the pineal glands of live rodents. The paper will appear in the journal Biomedical Chromatography and describes experiments that took place in Dr. Jimo Borjigin’s laboratory at the University of Michigan, where samples were collected. These samples were analyzed in Dr. Steven Barker’s laboratory at Louisiana State University, using methods that funding from the Cottonwood Research Foundation helped develop.
The pineal gland has been an object of great interest regarding consciousness for thousands of years, and a pineal source of DMT would help support a role for this enigmatic gland in unusual states of consciousness. Research at the University of Wisconsin has recently demonstrated the presence of the DMT-synthesizing enzyme as well as activity of the gene responsible for the enzyme in pineal (and retina). Our new data now establish that the enzyme actively produces DMT in the pineal.
The next step is to determine the presence of DMT in cerebrospinal fluid (CSF), the fluid that bathes the brain and pineal. CSF is a possible route for pineal-synthesized DMT to effect changes in brain function. Successfully establishing DMT’s presence in this gland adds another link in the chain between the pineal and consciousness and opens new avenues for research.
... Link
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DMT-Nexus member
Posts: 12340 Joined: 12-Nov-2008 Last visit: 02-Apr-2023 Location: pacific
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interesting..I have always thought for some reason that DMT likely will be found to be produced via the pineal gland in humans..only time shall tell. Long live the unwoke.
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DMT-Nexus member
Posts: 793 Joined: 23-Oct-2011 Last visit: 22-Aug-2014 Location: arcady
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What's next--will rat pineal glands be found to release a bunch of endogenous rat dmt during near rat death experiences? "Whoever undertakes to set himself up as a judge of Truth and Knowledge is shipwrecked by the laughter of the gods." Albert Einstein
I appreciate your perspective.
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☂
Posts: 5257 Joined: 29-Jul-2009 Last visit: 24-Aug-2024 Location: 🌊
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RatPineal wrote:Botanical Bliss wrote:Bump for interest.... anybody come across anything else on this subject? Interesting update from CRF today: CRF wrote:We’re excited to announce the acceptance for publication of a paper documenting the presence of DMT in the pineal glands of live rodents. The paper will appear in the journal Biomedical Chromatography and describes experiments that took place in Dr. Jimo Borjigin’s laboratory at the University of Michigan, where samples were collected. These samples were analyzed in Dr. Steven Barker’s laboratory at Louisiana State University, using methods that funding from the Cottonwood Research Foundation helped develop.
The pineal gland has been an object of great interest regarding consciousness for thousands of years, and a pineal source of DMT would help support a role for this enigmatic gland in unusual states of consciousness. Research at the University of Wisconsin has recently demonstrated the presence of the DMT-synthesizing enzyme as well as activity of the gene responsible for the enzyme in pineal (and retina). Our new data now establish that the enzyme actively produces DMT in the pineal.
The next step is to determine the presence of DMT in cerebrospinal fluid (CSF), the fluid that bathes the brain and pineal. CSF is a possible route for pineal-synthesized DMT to effect changes in brain function. Successfully establishing DMT’s presence in this gland adds another link in the chain between the pineal and consciousness and opens new avenues for research.
... Link Very interesting, thanks! You should make a thread on this
<Ringworm>hehehe, it's all fun and games till someone loses an "I"
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