I just have a couple of questions. I want to get to know everything i take, so i planned on first just seeing what the effect of just syrian rue are. I was 3-4 grams just to get my feet wet. Then i want to take 3-4g of rue and smoking some 10x caapi changa with a 1:1 ratio(should last a little longer than the normal 10-15 minute trip right). Then finally, 3g rue with 50-75 mg freebase, maybe more since i have a dense body(220 lbs).

First question. I planned on taking my rue next weekend however, i became very sick a few days ago and have a 10 day antibiotic prescription that my last dose will be sat morning. Is it safe for me to take rue at 9pm if i take my last anitbiotic at 6am?

Second question. what should my smoke dosage and oral dosage be? There is a very fine line for me because i dont want to waste a trip by doing to little, but at the same time i dont want to do too much and have a rough ride. I never measure my changa, i just load up the bong and ripped until space shakes. I'm thinking 1 moderate pipe hit with 3-4g rue should be good...right? Orally, what is a good beging ratio(spice to body weight)? at 220lbs would 50mg even do anything to me? Should i be thinking closer to 100-125mg?

Thank you for any advice

Hi there.

What antibiotic are you taking? I haven't heard of any rue/antibiotic reactions, but that doesn't mean they don't exist. From what I've found, the MAOI dietary restrictions are pretty much not an issue with rue, it's really drugs like SSRIs, tricyclics, MDMA and DXM that you really need to avoid. I don't believe antibiotics would be a problem, but you should probably search for your particular antibiotic to make sure.

As for your smoked dosage, you should probably get a better idea yourself first by smoking some without the use of any rue or caapi. Once you know what gives you good effects, drop it down by about a third when combined with rue.

For your oral dosage, I'd go toward the high end, but that's just me. I've got a pretty high tolerance and I typically don't get decent effects until around 200mg. I've got about 60lbs on you and I have a high tolerance, so take that into effect. I'll cautiously recommend that you go for 125mg. That would be about .6mg per lb of body weight, I needed a bit more than 1.2mg per lb of body weight for my breakthrough experience.

Also, do you have any caapi available for ingestion along with your DMT? Rue is interesting when combined with DMT, but I find that the addition of THH makes all the difference in the world. I never get any of the crazy euphoria in my DMT experiences unless THH is included. It also seems to provide some guidance. If you can take some caapi extract orally, I'd highly recommend it. I haven't tried smoking caapi as of yet, but I'd imagine the smoked caapi will add quite a bit as well. Best luck.