member for the trees
  
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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..i remember reading a paper trying to figure out the chemistry of acacia gums...very,very long chains/polymers(of identical units) i recall..will serach for it...
..also, when there is an alkaloid mixture in a plant, could they not (until separated by test/observation) constitute a kind of macromolecule?
(the whole is greater than the sum of it's parts, sort of gist). Or at least the CNS may interpret the mixture as a 'macromolecule'.
This could partly explain the insistence by many that plant experiences are different, even if the chemical constituents are the same.
(also a bit like the quantum physics idea that the act of measurement affects the result...)
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analytical chemist
  
Posts: 7463 Joined: 21-May-2008 Last visit: 03-Mar-2024 Location: the lab
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receptors generally process small molecules and peptides; the receptors themselves are macromolecules, (i.e 7TM receptors) the different plant experiences are likely due to other active compounds exerting their effects on other receptor subtypes or other receptor systems, resulting in various visceral [somatic] side effects "Nothing is true, everything is permitted." ~ hassan i sabbah
"Experiments are the only means of attaining knowledge at our disposal. The rest is poetry, imagination." -Max Planck
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member for the trees
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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.. Quote:the different plant experiences are likely due to other active compounds exerting their effects on other receptor subtypes or other receptor systems, resulting in various visceral [somatic] side effects
agree heartily benzyme..  ..have found a reference to "tryptamine isomers" (though these mainly seem to be reaction byproducts) in Trends In Analytical Chemistry Vol.29 No.4p.289 ..i've only just started studying this paper, hope it's useful to some of you...
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member for the trees
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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benzyme you wrote Quote:receptors generally process small molecules and peptides; the receptors themselves are macromolecules, (i.e 7TM receptors) ..fascinating stuff.. found these articles 5-HT1A gene promoter polymorhism... and Association between triallelic polymorphism of the serotonin receptor...
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member for the trees
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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..i found this on p.109 of J.Ott's "SHAMANIC SNUFFS or ENTHEOGENIC ERRHINES" paper (thanks for posting Untm) article downloadQuote:
Iacobucci and Ruveda [1964] showed that seeding a recrystallization-solution with crystals having a 146-147°C melting-point gave only crystals of that type; the lower-melting-point
isoform (their initial isolated material melted at 123-124°C) could not be regenerated
by reversing such operation. By manipulating some conditions of recrystallizations
(always from ethyl acetate), I was able to produce crystals melting at 145-147°C, and
also found seeding a saturated-solution of my lower-melting-point crystals with the
higher-melting isoform gave only crystals of the latter type. This phenomenon has
been reported for DMTfree-base, which likewise seems to crystallize as three distinct
isoforms from hexane; melting-points from 44-74 °c having been reported [Shulgin
& Shulgin 1997].
..just to keep the issue alive (though i accept benzyme's explanation that this could be casued by impurities of less than 2%)...
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member for the trees
Posts: 4003 Joined: 28-Jun-2011 Last visit: 27-May-2024
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..this is my quote of the week, care of glof, hi glorf Quote:
it should be interesting (to those making the voodoo magick-ish argument of different melting forms of DMT having different effects) that the molecule is a bit plastic, not exactly the same even within a crystal modification - bonding with neighbors bends bonds. it appears to be a simple case of different arrangements being possible.
..the findings glorf references in dimethyltryptamine polymorphism? bring a new level of attention to detail of these fascinating and seemingly simple molecules...
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