Greetings everyone,

I am an undergraduate chemistry student in my junior year now. I want to first thank, well, everyone here for this site (mods, creators, contributors, etc.) It has been an invaluable resource to...comfort my curiosities.

I have great interest in computational biochemistry. I've been working on a project to help locate binding pockets within the monoamine transporters. Recently, I've been looking at DAT, trying to determine cocaine's binding site to aid with drug development for addiction. I imagine I'll go to grad school for physical (bio)chemistry. Yep, I'm a nerd, and I'm proud of it. I'm still humbled by all of the great minds around me, and realize that I still have a lot to learn (which is partly why I'd like to participate in discussions here).

I've mainly only ever used psychedelics- LSD, 2c-x's, DMT, DPT, 4-aco-DMT, salvia, etc. DMT is by far my favorite as it seems to have provided the greatest amount of spiritual/personal growth (followed closely by acid). I don't need to repeat what all of you already know, though.

I look forward to posting in the nursery the next few days. I'll share my extraction tips/blunders/etc. when I have a bit more time to type them out. I have a few somewhat interesting/atypical trips which I'd like to write about as well.

Anyway, it's nice to have finally signed up here. Hope all is well.

-latent

Awesome! Welcome to the Nexus! Will be glad to hear more from you for sure

So did you try dmt orally too or only vapped? How did you find that?

I've only vaped DMT so far. I plan to experience ayahuasca either this weekend or the next. I feel somewhat comfortable taking it orally now after 20+ intense vaped trips.

Really, I think I've just been overcautious about using an MAOI. I've had a terrible paranoia about drug/food interactions, but I'm finally getting over that.

Should I post my trip reports/etc in this thread, or should I throw them in "First steps in hyperspace?"

I guess by now you've read that reversible MAO-A inhibitors such as harmalas do not really pose a thread in term of interaction with food (though of course still be careful if you're taking medication, also careful about mixing stimulants and harmalas).

What dosage are you considering taking for ayahuasca?

You can post your trip reports/etc here in this thread or also in first steps in hyperspace, wherever you feel its the right place im sure will be fine

Yeah, just read up on that in more detail today. I have syrian rue, which is supposed to be a bit stronger than the alternatives, but I'm not too worried. I think I'll just fast for a day or so beforehand to ease my mind. As for dose, I was thinking 3g rue and 10g of mhrb. Does that sound reasonable, or would you recommend starting lower? I'll try subactive doses of each the night before to test for allergies. That'll help calm my nerves a bit too. (Also, take into account that it's pre-powdered bark that has been around for about half a year).

I'll write up a report or two tomorrow and post them here.

Welcome, friend. We can never have enough of you smartified scientifical types around here.

I look forward to hearing more about your work - both in the lab and your own consciousness - and I'm sure you'll be a great addition to our humble kamoonity.

Thanks Art.

Also, I've had a question that I haven't been able to find the answer to (or if I did, I forget what it is).

Does anyone know if, after a naphtha pull, you could evaporate most of the solvent off using a heating mantle/round-bottom flask? Would the heat cause too much oxide formation for this to be feasible?

Edit: Never mind. It seems like their boiling points are too close for a distillation to work well. Silly me.

Welcome to the nexus!

10g MHRB with 3g rue is a pretty substantial dose for some; if its your first time using this approach I would suggest a lower dose, to gauge your personal response.Some people can get where they want to go with alot less than 10g.There are plenty of good threads on this, plus many mamy other topics, here;have a good look around befoe deciding.

Welcome! I love nerds!


If one has the said root bark in pulverized form, can one just mix that with water and drink?
What's rue?

10g MHRB is way too large dose!!! Please do not take all this much! Start with 3g rue and 3g mimosa.

Standardkiwi, rue = syrian rue = peganum harmala. Its a plant that we can use as a substitute for the ayahuasca vine, because it also contain the harmala MAOI alkaloids.

And no please dont drink the water with the rootbark mixed in. I would guess you wouldnt be able even if. you wanted because its gonna taste so bad you're gonna purge before finishing your glass. Do the 3x boils/simmers and at the end filter the solids. Even then it will still taste pretty horrid, but you might be able to keep it down Some people do egg white tannin removal tek, search the forum for that, as it might help with removing some of the inactive substances which make it taste bad (adstringent)

I had planned on taking 10g because my pulls with this material have been about half of what they have been with previous root bark which I have ordered. I figured it would be roughly equal to ~5g of decent quality root bark.

I realize that it would be wise to start with a lower dose- especially the first time. I think I'll take the suggestion of 3g/3g to test the waters.

Thanks.

I've been working on a trip report to be posted later tonight. I've never written one (and it has been a few weeks since this experience), but I'll try to include as many details as possible. I definitely hit ++++ once before, but this trip was sort of beyond...err...parallel(?) to that, in a way. Of course, most details are cloudy, but I'll try to relate the state I reached.

Hope everyone is doing well.

Namaste!

Well, here's the trip report. I had difficulty writing it because there were a few things I couldn't describe. The main ideas/gist of why I thought this was strange are included, however. Enjoy!


Dimethyltr…what?

Background:
I started using psychedelics a little over two years ago. I’m fairly well versed with the psychedelics I have done: LSD, DMT, DPT, 2C-i, 2C-e, 4-aco-DMT/Mushrooms. I understand that every trip can be much different, even with the same drug. However, every trip I’ve had (with these different drugs, separately) seems to have a certain character to it- a familiar feeling , a similar thought pattern, memories of past trips, etc. Most of my trips, including this one, have taken place in the same setting. Mindset is generally the similar. I don’t have too many emotional problems. Out of the dozens of times that I’ve tripped, I’ve never had a dark/bad one. I become irritated with physical discomfort at times, but it’s generally a nonissue.

The trip:
I loaded roughly 60mg of pretty pure (white crystals) DMT into my newly purchased happy valentine glass (i.e. freebase) pipe from eBay (lol). I have had experience with larger amounts before- from the same batch, too. I smoked nearly all of it in several hits. I handed the pipe to my fiancé, laid down, and prepared myself for hyperspace. The familiar ego dissolution began almost immediately. Everything felt similar as my previous trips.

But wait! This isn’t the DMT trip that I know and love. Breakthrough had occurred, and I was plopped down into a seat in a classroom. The kaleidoscoping patterns completely disappeared. There were students in the classroom. There was this feeling that I knew them, but I didn’t know who “I” was. The place felt familiar as well. It was futuristic. However, things were different. The teacher poofed into existence. At that moment, my ego came rushing back. I recalled smoking DMT, but I was still immersed in this world. I tried opening my eyes, but it had no effect. I tried (physically) verbally communicating to the teacher, hoping that my fiancé would hear me. She reported after the trip that I didn’t make a noise, nor did I open my eyes. She said I was laying there the entire time with slow, deep breathing, not making a peep.

So, I figured that since I was in an alien classroom, I figured I’d ask a question. I’ve had a little trouble in my Physical Chemistry class recently, so I asked her to explain what I didn’t know. Equation after equation came off of the board and went straight into my brain. I saw them rearranging, morphing, etc. It was so vivid that if I knew I wasn’t on DMT, I’d have thought it was a lucid dream (I can generally have these when I want. After 3 or 4 years of practice, it’s usually easy for me to enter lucid dreams when I please.). This occurred for the remainder of the trip. On the comedown, I grabbed my P-chem homework. I completed 15 questions of it in about 45 minutes…a task which would have usually taken me four or five hours. A few hours before the trip, I looked at the problems. I had an idea of how to do roughly half of them. The other half, though, I had no idea how to even start. The rest of the students in the class spent at least three hours working through them. To my surprise, I had all of the problems correct when it was handed back.

I’m writing this trip off as being somewhat atypical. I’ve never remembered a DMT trip in this much detail at that sort of dose. In fact, I felt like I had remembered everything immediately after. It’s as if I was watching myself in the trip, but me the observer and me the participant were constantly communicating. I wonder if the DMT had made me pass out and enter a dream state? I’m not sure. I have some theories about why this trip was strange, but I’d like to hear what you think first.

Thanks for reading! :]

Although I do not use Naphta, only Hexane, Heptane and DCM, I regularly distill solvents and usually have good yields.

Do you perform a fractional distillation?

Naphthas and generally aliphatics are perfect for freeze precipitation if one wants to get the dmt out of them. After this step they can be safely distilled (little if any dmt stays in the aliphatics after freeze-precip), so there's no need for fractional distillation.

DCM pulls on the other hand can be distilled as is due to the low boiling point of dcm. This will leave you with a oily yellow residue comprising of dmt, dmt n-oxide, other alkaloids and rest oily/fatty crap. Mind you, SWIM has never bothered to straight distil dcm pulls though, because the residue'll be more difficult to clean.

Finally, nice to have you around here! We do need more of the science types!Which softwares do you use for your modellings? I also did some back in the past, it never won me though over the good old "wet" bench-work.

I was just curious if there was a way around freeze precipitation using naphtha (because I generally get fairly clean pulls with it). I haven't used any other solvents up to this point. My curiosity came from my impatience with waiting for a freeze precipitation.

I have mainly used Molecular Operating Environment (MOE) so far. VMD is used on occasion. Most of my work at the moment is programming new code to be used in the lab (pocket identification/etc). MOE has a built in language that can be used to write programs to be used with MOE. I'll be publishing (hopefully) within the next half year or so. Will definitely post about it when I do.

No, I do simple distillation instead of reduction in order to minimize solvent losses.

Wait, do you mean that you actually vaped dmt in a classroom ?

MOE is ok

i prefer Schrodinger Suite and Pymol;
also dabbled with Sybyl

in windows, Accelrys Discovery Studio is tops. ligandscout is cool too

welcome to the geekdom.