I am sensitive to RIMAs. On two occasions i have received powerful headaches from them.
For this reason i have all but sworn off the rue, and im not sure i feel safe with isolated harmaloids anymore.
A while back while camping i did changa ( passionflower changa, with a bit of damiana ) that was pretty saturated with harmaloids i had extracted from syrian rue. We did this on and off for a week, never more than 2 bowls in a day, probably consecutively for a couple days. This is not my normal level of use...we were camping, it was a beautiful place, i felt the call.
Anyway, i was stupid. ~4 days in i got a splitting headache after most likely eating some of our camping food which had tyramine in it. This instance wasnt so bad. I would have thought it was just a normal headache if i hadnt had one before...
When i first discovered DMT, i consumed rue seeds and smoked it consecutively for probably 5-6 days once. This was not a breakthrough dosage. However, after some physical exertion i experienced, eventually, a huge, quick-onset migraine that totally immobilized me. I was writhing in my bed, in a huge amount of pain. Im pretty sure i didnt experience migraine blindness from it but its possible. For a month after i had trouble exerting myself without getting a headache. I couldn't do jumping jacks, walk up stairs too long, ETC.
I didnt realize what it was initially. Went to the doctor, got prescribed medication.
Really, only caffeine fixed it. That pointed, to me, to the problem being vasoconstriction, because caffeine is a vasodilator. Then i realized it was the RIMAs.
It's been a year since then. I feel mostly the same, and i havent had a headache from rue besides those instances.
Thats not something smart to do up there, but RIMAs are safe for most people with careful use. But the reason i am posting this is because i have a question. Does anyone know if i could have gotten brain damage? I dont feel as if i have, but im really worried about it...

In the absence of ongoing neurological symptoms its most unlikely that you have sustained any significant brain damage.

Do you usually suffer with migraine headaches?

It has been shown in some individuals who have frequent severe migraines that after many years of this they can get a degree of 'brain damage' (perjorative term) which is manifest on an MR brain scan as deep white matter changes which are felt to reflect areas of vascular compromise.

Headaches, whether migrainous or not, are a fairly common side effect of MAOIs.

No, i dont have migraines normally. But what i had that night felt like a flippin' aneurism. So i was worried.
'preciate the input.

When I first started working heavily with rue, I had some decently nasty hangover's after the effects wore off. As you mentioned, caffeine seemed to help.
I know some people have issues with caffeine and other energizers in combination with, and even after RIMA's are in effect, but I have never had an issue when used in moderation.
I always drink a couple cups of green tea and eat fruit and veggies afterwards...haven't had a harmala hangover since.

They really are absolutely terrible headaches....though I doubt any long term damage was done.