To have the relaxing qualities and nausea inhibition is the best of both worlds as a dual addmixture combo.

Are there any issues with this combination?

And is there any synergistic expression that anyone can inform me on.

Thanks for your considerations...

Nothing wrong at all if you keep the dosage extremely low. However, I see no point of adding Datura stramonium. Datura inoxia don't have solely scopolamine, but also around 20% hyoscyamine. A few more seeds of Datura inoxia than normal should work as intended.

I have used both at the same time. I guess I could feel the difference (I usually only take datura s.) that the inoxia added but it was slight.

So to achieve the same hyoscyamine content as 3 seeds Stramonium, I would take 15 seeds Inoxia.
Would this be too much Scopolamine?

eh... I'm not sure. My line in the sand has been 10 seeds a day. I have never taken more than 7.

You know what, I was wrong. Datura inoxia is about 97% scopolamine. I was thinking about Datura stramonium, which regularly have around 20% scopolamine and 80% hyoscyamine. I am sorry for the mix-up.

You could without any fear of unwanted side-effects use 3 seeds of D. inoxia and 3 of D. stramonium together. You can up this to 5 of each if you like, but more than that is not advisable.

Can anyone describe the differing effects when exceeding the standard below threshold medicinal dosages?
For each of these seeds.

For example 10-15 or 15-20 seeds.

Thanks for your time...

They are similar in how they feel at some level that’s hard to describe. D. stramonium is a stimulant and at those doses you can really feel it. It’s very nice actually. D. inoxia is a sedative, but at that dose the sedative effect is mild. It’s great for relieving muscle tension, cramping, and helping you sleep. Both at those doses produce euphoria, but D. stramonium produces more euphoria. Also, both at those doses may cause dry mouth, but D. stramonium produces more dry mouth symptoms. Neither really has any mental effects at those doses. There might be some slightly noticeable, but it’s not worth noting unless the seeds are super potent.

Not that I have any plans to exceed 10 of each, but i was wondering what one would still consider a safe dose for a 200+ pound Dude.
Would, for example, 25 seeds "Total" still be a safe dose as far as health and not-ending up in the rubber room.
Thanks again...

I think that dose would be safe. It's not a very sharp and thin line between no mental effects and a sudden delirium. There is a stage in between, that is a stage of clear intoxication, but no delirium.
The reason you should avoid reaching that stage, is because the line between the non-delirium intoxication and the delirium IS very thin: if you try to go for the 'safe' intoxication, you may wind up with the delirium instead.
So if some people have taken ten seeds without even getting the intoxicating effects, i think 25 seeds will not get you a delirium.
But there is a good reason not to want to stretch the elasticity of the line too far.