Hello,
Is it safe to take MDMA 30 minutes after smoking changa.What is the harmala halflife and what is minimum time to be weit between changa and mdma

Simple answer: avoid such combinations.

It's relatively easy to research. Search "interactions of harmalas and mdma" or "mdma contraindications."

Be well.

One love

It's a very dangerous combination like Voidmatrix already mentioned, potentially lethal. The plasma elimination half life for harmine is 1-3hrs according to Wikipedia, which is very close to moclobemide a very similar compound regarding pharmacology. A direct switch can be made from moclobomide to most SSRI's after a 24h washout period, although MDMA isn't a SSRI I believe the same rules apply when switching from harmalas to MDMA. If going from MDMA to harmalas I'd wait two weeks or more for MDMA and its metabolites to clear out.

To echo what the others have said, it's best to avoid combining MDMA and changa/harmalas.

That said, I've seen enough people do it without adverse effects that I no longer believe it's quite as dangerous as one would be lead to believe by just reading the generic contraindication information.

I'd hypothesize that using harmalas with MDMA would significantly increase the neurotoxicity since MDMA basically breaks open the SERT pathway and allows other neurotransmitters to be taken up and oxidize inside the neuron. Since harmalas increase the concentration of neurotransmitters in the synapse, it stands to reason one would experience a proportional increase in neurotoxicity when combining harmala with MDMA. This would be an interesting experiment for someone with the means to test it.

We don't have data on the half life of harmalas when smoked/vaporized, it's most assuredly shorter than oral or sublingal administration, but a good rule of thumb is to go with the oral numbers and have a gap of at least 3 days (72 hours) in either direction.

I smoked dmt very few times on the comedown of mdma,it didnt feel good at all...i knew right away there was a conflict going on in my brain,just felt off man.

This neurotransmitter hypothesis is an interesting one, although a Spanish research team showed that there was a metabolite of MDMA (combined with 2 molecules of glutathione via S-linkages in the 2 and 5 positions), and that it plays a crucial role in MDMA neurotoxicity. I'll have to have a dig around for the reference.

Changa specifically includes harmala alkaloids along with the DMT; the RIMA properties of the harmala alkaloids are what is considered to be risky in combination with the serotonin-releasing properties of MDMA.