I remember there was a post of bancopuma, in wich he described a very unpleasant experience he endured, with a combination of lion's mane and 4-AcO-DMT.

Now i don't know the pharmacological mechanisms behind the efdects of lion's mane, but i do know that numerous nootropic drugs either stimulate glutaminergic activity, or act on glutamate receptors. And also that with glutamate, excitotoxicity due to overstimulation can be an issue.

So in the light of that, i don't know if it is wise to combine psychedelics with nootropic drugs. Many psychedelic's stimulate glutaminergic activity as well. I suppose that, since LSD, psilocin and mescaline do, it would at least be wise to assume that most of the psychedelic tryptamines do, most of the lysergamides, and most of the phen's.

But there are quite a few people here who are much more knowledgeable than me on pharmacological stuff, and perhaps some of them could shine their lights on this matter.

I had a professor who researched lion's mane properties and I've been taught something about it, but I'm not an expert.

Basically some terpenoids in lion's mane stimulate the synthesis of nerve growth factor and therefore neurogenesis in the hippocampus. The newborn neurons fire action potentials at a higher frequency and this results in larger amounts of glutamate being released. This effect has been observed in the hippocampus but not in the cortex.

They can also increase monoamine neurotransmitters in the hippocampus through an unknown mechanism. It has been speculated they might act as receptor agonists or as reuptake inhibitors.

But I don't think lion's mane could contribute to excitotoxicity. Infact LM extract can protect cells from glutamate-induced excitotoxicity by hyperpolarizing their membranes and scavenging reactive oxygen species.

[[ If your talking about nutropics used for ..memory boosting...and lucid dreaming... ]]

I came up with the idea years back on ..dmt nexus..of trying ...[galantamine]...with .[vaped DMT] and it

was tryed and made the experiance ... VERY STRONG! ... but no harm done...


There are many other weaker.. nutropics ...that should not cause harm...and might even improve the spice experiance some?/



4.. to ..8mgs of [natural galantamine] [for lucid dreaming]...[you can buy in a store without prescription.... . is a normal lower dose...make shure the galantamine is ..[natural galantamine]
[NOT!.. prescription..lab made galantamine!].....because precription galantamine is much stronger than...
the safer natural galantamine extracted directly from the flower...that us lucid dreamers used...



read older nexus posts below when i was .... Starway 6..


I think the first post below just got a bit freaked out because the galantamine
[sharpened and amplified the dmt experiance some] ...and caught him by surprise...
Galantamine is a mind sharpening memory boosting drug that boosts acetylchonine within the brains neurons.


[also...[Natural Galantamine] taken at safe dosages ...4...8...or 12...mgs does not cause
[bradycardia.] in a healthy person...

When i took...[NATURAL [G] for lucid dreaming [[products that used to be on line.....
called .. [Briliant Dreams]..or.. [Dreamamins]....used for lucid dreaming..... i used it 3 times a week for months...it never caused me any harm maybe a little sleep loss and once and a while a minor headache that went away within an hour...



Ayahuasca + galantamine trip report Options

jivangilad
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Posted : 2/5/2015 9:09:38 PM
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I decided to try galantamin + ayahuasca.
I took 8 mg of galantamine and then my usual dosage of Ayahuasca..
1.5 gr syrian rue powder + 1.5 mimosa powder with glass of water..
It felt like normal. mild Ayahuasca experience nothing special.
When effect declined maybe an hour/hour and half later, I took about 1.6 gr syrian rue + 2.2 mimosa.
Usually With this dosage I feel full Ayahuasca experience, not too overwhelming.
This time it was very strong. Too strong for me.
I felt all my pain and unresolved issues are coming together. I started a long cycle of vomiting trying to vomit and cannot vomit. To ground myself and not dwell in negativity I walked. I found it hard to walk properly and stumbled. At one point I walked on the edge of the water pool, and fell into the water.
Experience felt like eternity.
I was lucky that it was daylight. It might have been terrible in night time.
8 mg is definitely too much, and definitely not for beginners.
It was healing, but this intensity was unnecessary.

Conclusions.
Combos can be dangerous.
In the west we have plants that don't exist in the amazon combos are yet to be explored.
Though for me it is hard to say not to explore. I will be more cautious next time with other unexplored additives.
It is also problematic to do this strong unknown things without some kind of guidance.
I wont find a shaman/ayahuscero where I am, but maybe some other spiritual/ psychological figure .

The-Nexian.me
Psychedelic news, articles, interviews and art from the DMT-Nexus and other sources.

Chan
#2
Posted : 2/5/2015 9:56:51 PM
QUOTE

Another Leaf on the Vine


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Last visit: 24-May-2021
There's a clue in your post.

You took a reasonable dose of Mono-AMINE-Oxidase-Inhibitor, to boost the effects of the AMINES you planned to consume.

Then some trypt-AMINEs, having pre-dosed with some galant-AMINE.

Galantamine, with no known use in aya-combos, but potent neurochemical properties and a known trigger for bradycardia.

I don't mean to sound harsh, but you are currently messing with things you don't appear to understand.

Read more, eat less.

You're damn right there are still combos to be explored, many of which are likely fatal Twisted Evil

“I sometimes marvel at how far I’ve come - blissful, even, in the knowledge that I am slowly becoming a well-evolved human being - only to have the illusion shattered by an episode of bad behaviour that contradicts the new and reinforces the old. At these junctures of self-reflection, I ask the question: “are all my years of hard work unraveling before my eyes, or am I just having an episode?” For the sake of personal growth and the pursuit of equanimity, I choose the latter and accept that, on this journey of evolution, I may not encounter just one bad day, but a group of many.”
― B.G. Bowers

ॐ

starway6
#3
Posted : 2/6/2015 2:01:28 AM
QUOTE

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I was wondering when someone would try Galantamine with DMT and now this report..

Concidering you used an maoi with your dmt with GM ..that may have caused a negitive effect..

Natural ..[non prescription]..Galantamine has long been used for lucid dreaming and works quite well ..

Galantamine derived from the [spider lilly] .. or [snow drop] flower causes awesomely vivid dreams often becomming lucid or an out of body experiance...

If you would have just smoked some dmt an hour after taking some natural galantamine your results may have been more [positive] with an increase in abuility to recall the dmt experiance better...[just a theory]

Did you remember the details of your trip better with Galantamine?

Just a theory ..if you had just smoked some dmt [without rue or caapi]...an hour after taking 4mgs of natural.... [non prescription] galantamine it MAY have been a nicer experiance with a posibly stronger memory of the details...

Ive been wanting to try some galantamine with smoked dmt but mixing an maoi makes it a higher risk of bad trip...



starway6
#4
Posted : 2/6/2015 2:26:53 AM
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Man From Chan Chan wrote:
There's a clue in your post.

You took a reasonable dose of Mono-AMINE-Oxidase-Inhibitor, to boost the effects of the AMINES you planned to consume.

Then some trypt-AMINEs, having pre-dosed with some galant-AMINE.

Galantamine, with no known use in aya-combos, but potent neurochemical properties and a known trigger for bradycardia.

I don't mean to sound harsh, but you are currently messing with things you don't appear to understand.

Read more, eat less.

You're damn right there are still combos to be explored, many of which are likely fatal Twisted Evil



The only galantamine that is most risky is the ..[prescription kind].. the natural leagle version of galantamine is quite safe found on line at [Dreamins .com] or brialiant dreams on line..also [Galantamind] is the kind i have..and is leagle and safe to take...
I have taken the stuff for months on end and the worst thing ever happened was ocasional insomnia ..
Natural galantamine has been used ..SAFLEY..by elderly people with memory decline and other health problems..under a doctors care up to 30 mgs a day for months and the patients eventialy develope a tolerence for it and most side effects like vivid dreaming will stop and many of them benifit from the memory boosting effects of galantamine...

Those of us in the lucid dreaming comunity take galantamine in doses of 4mgs...8mgs...12mgs for the purpose of lucid dreaming...and we dont take it more than 2bor 3 times week to avoid a tolerence...

For healthy people...Natural galantamine is ..[very safe!@].. at these doses ony precription galantamine is more risky..

Also you spoke about the posibility of bradycardia. its just a posibility if one takes too much with existing health problems..
I have never experianced this bradycardia ever!

But when one is using seryian rue or another maoi the risk of bad trip can happen..
I think that galantamine ..[with only dmt]... could be an experiance easyer to remember but everything has its risks and one should research before mixing any thing!

Chan
#5
Posted : 2/6/2015 7:33:44 AM
QUOTE

Another Leaf on the Vine


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Quote:
But when one is using seryian rue or another maoi the risk of bad trip can happen..


Damn right. If you're going to use MAOIs, you need to understand you are selectively shutting down one of your body's safety mechanisms, and you need to understand the dangers of subsequently consuming many amine-based compounds, including several popular club-drugs.

The MAOI effectively boosts the amine dose by an order of magnitude or more, so OP effectively took maybe 80mg of galantamine, or even more...

I'm sure when used responsibly, without MAOIs, galantamine is perfectly safe.

“I sometimes marvel at how far I’ve come - blissful, even, in the knowledge that I am slowly becoming a well-evolved human being - only to have the illusion shattered by an episode of bad behaviour that contradicts the new and reinforces the old. At these junctures of self-reflection, I ask the question: “are all my years of hard work unraveling before my eyes, or am I just having an episode?” For the sake of personal growth and the pursuit of equanimity, I choose the latter and accept that, on this journey of evolution, I may not encounter just one bad day, but a group of many.”
― B.G. Bowers

ॐ

jivangilad
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Posted : 2/6/2015 8:53:45 AM
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I definitely remember the experience much sharper.
I don't think galantamine turned the trip specifically into the bad side (like datura can do)
It made things much more intense then normal. Maybe like taking much more DMT.
I think it could be added in smaller dosages.

starway6
#7
Posted : 2/6/2015 4:48:21 PM
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jivangilad wrote:
I definitely remember the experience much sharper.
I don't think galantamine turned the trip specifically into the bad side (like datura can do)
It made things much more intense then normal. Maybe like taking much more DMT.
I think it could be added in smaller dosages.



This makes sense that the trip was more intense using galantamine ..because galantamine boosts chemicle comunication within the brain at recepter sites..

Thats why those of us who use galantamine to lucid dream always remember our dream experiances much more sharply because the dream is so much more vivid!

So why shouldent we remember more details of our DMT trips adding galantamine to the stack...

The PROBLEM of NOT remembering much of our smoked DMT trips has been a well known with the fast moving vaped DMT experiance...

It would be very interesting to know how a small dose of [natural galantamine] taken 30 45 minutes before a vaped dmt trip [using no maois] would effect the memory of the experiance!

I believe...Natural Galantamine reaches peak blood plasma levels within one hour after consumption..

It would be awesome! to be able to take more of the DMT experiance back in vivid memory to put on paper or in form of art to share with others ...

So in effect.. by taking natural galantamine first.[on empty stomach]...before smoking DMT .one is supercharging their own chemicle comunication within their own brain to experiance the trip with all.. [sight.. sound..smell multi emotions switches within the brain turned up to near full capacity!

I think trying smoked DMT with a low.. 2..4..or 8mgs of natural galantamine taken 45 minutes before vaping mixed in orange juice.. might prove to be a more positive memory boost to the experiance ..
Judging by your report above that [the experioance was more intense] points in the direction of boosted [experiance during trip].. and [stronger memory] to bring more back to baseline!!

Again this ..[stronger memory].. [and increased abuility to use criticle thought]...effect is how galantamine effects humans while dreaming because the boosted criticle thought is used to realize that they are dreaming and nothing can hurt you in a dream so your freedom is unlimited durring the dream...

DMT experiances are much like dreaming while awake this is all very interesting!

Galantamine may be the key to boosted criticle thought durring trip and much stronger memory
to bring more of the treasured memory back to base line!

Again this still has to be proven but seems very posible...!

jivangilad
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Posted : 2/6/2015 8:17:01 PM
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starway6 wrote:



This makes sense that the trip was more intense using galantamine ..because galantamine boosts chemicle comunication within the brain at recepter sites..

I think I agree with you.
So the main difference was not that the quality of the experience changed, but that it was intensified.
It is possible that for some one that doesn't have a big problem of dealing with their negativity it wouldn't be too difficult.

starway6
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Posted : 2/6/2015 10:37:58 PM
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Today..I just tryed a very low dose smoked dmt test and it apears that it does make the experiance stronger and easyier to remember details!

It will take more tests but today i vaped only 10 drops of acacia DMT tincture ...
[ equaling about 10 or 12mgs of dmt]..with only 2mgs of galantamine [one half capsule] and it felt like almost twice the dosage..

The way i did this was to take one 4mg capsule of [Galantamind] containing 4mgs galantamine with choline and pantothenic acid then emptyed out the capsule and mixed it good and put exactly half into a capsule...equaling about 2mgs of galantamine..

Then i took the capsule about twenty minutes before i ate lunch alowing the galantamine to be absorbed before my food..

I made shure i waited atleast 60 minutes time enough for ..peak plasma to take effect.. of the very small dose of galantamine...

2mgs isnt much galantamine but this was just a test with a very low dose of DMT tintcure ..

I only used 10 drops of dmt tintcure ......
[a strong experiance with my tintcure starts at 25 to 30 drops]...so this was quite a low dose...

After vaping my tintcure i noticed that if felt more like 15 drops or higher ..and i quickly got open eye visuals of breathing pulsing walls quite strong!

It seemed much more visual [oevs]early on than 10 drops should produce... and i then shut my eyes to observe CEVs that seemed twice as strong as they should be at that dose...

And my memory of details [even at this low dose] was quite good when i returned to baseline!

Durring the light trip.. my closed eye visuals took me down elegant hallways and coradores entering many diferent colorfull rooms of diferent sizes and shapes and a strong memory of beautyfull multi collored carpets floating by and clear intermitant visuals of people...
Many colorfull things made of cloth were very beautyfully woolven and i seemed to look into their very fibers..
Durring all this my mind was very sharp with a strong ability to use criticle awareness on everything i experianced...

And even now my recall of what i saw was defenantly better than a usual DMT trip...

My doses were so small ..im surprised at how strong the experiance was!

It will take more tests.. but so far the ..[Galantamine DMT combo].. shows promise of making the experiance more easier remember when when back to baseline...

Any one interested may want to try it..without an MAIO..

jivangilad
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Posted : 2/7/2015 6:07:39 AM
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Apart from the obvious use for dreams, I am going to check at time to help for meditation.
I would suspect the it can help to learn new behaviors/thinking patterns since it intensifies the experience.
So even in Ayahuasca it can be applicable not to help releasing negativity but more to learn new behaviors which Ayahuasca sometimes teaches us.
Or also learning new behaviors not in the context of Ayahuasca.
I suspect from the results after my trip that learning of new behaviors has been boosted in this session.

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starway7
Welcome to the DMT-Nexus » WELCOME AREA (new members can post here) » FAQ - All your basic questions and answers » Ayahuasca + galantamine trip report

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Could you list some other nootropics of concern here? There seems to be a pretty wide array of chemicals coined "nootropic," so am curious as to what one's may be of concern. I've even come across people talking about certain vitamins as nootropic.

Personally, I take daily lion's mane, reishi, and cordyceps daily, as well as L-Tyrosine, L-Phenylalaline, and choline, along with the my vitamins of B Complex, vitamin C, ginko, vitamin D, and a 200mg caffeine pill. I haven't really noticed any negative impact, but to be fair, I'm not going the distance that often.

One love

Well, there are probably more, but from the back of my head i think aniracetam, noopept, idra-21, sunifiram and unifiram, pramiracetam and oxiracetam have some glutaminergic activity. All of the so called ampakines anyway.

Luckily, thanks to cosmicriver, we can now say that lion's mane seems pretty safe and may even protect against excitotoxicity.

Most of these ampakines are synthetics, but my knowledge of these things is limited. There may be some herbal glutamate releasing drugs, because we know mescalin and psilocin are.

Cordyceps seems to be able to protect the brain from glutaminergic excitotoxicity as well, btw, like lion's mane.

I think what you are taking is probably safe voidmatrix.

I don't want to dismiss bancopuma's experience though. Maybe LM + 4-AcO-DMT caused the unpleasant symptoms through a different mechanism.

Lions mane..an edeble mushroom.. [is a brain food ]..is like eating food..probbibly .[i think its used as a food ingrediant]....probibly no noticable effect at all!.. with spice..

Natural Galantamine]... is reasonably safe...as acetylcholine booster..also.. ..Huperzene A.. has similar effects as galantamine..is a natural extraction from a plant reasonably safe..

[Galantamine and Huperzene A.. ...will defenantly effect the trip experiance!

Its posible that a high dose of choline which is ..[very safe]... could have a good effect on a spice trip..
The brain ..loves choline... and uses it regularly!

There is a long list of other nutropics one must reaserch them before trying them with SP..

Galantamine and huperzine are both NMDA-antagonists, so they probably even offer a mild protection against glutamate excitotoxicity.

Normally galantamine is extracted from the ..spider lilly flower...or the ..snow drop flower...

I just found [ Galantamine]..is also found in the ...Dafodill species ..

galantamine is known to boost or bridge chemicle comunication between receptors in the brain..

Thats why i believe that some galantamine [between 4 to 8 mgs].. [4mg]s might be a more cautious dose... taken.. [one hour].. before vaping..SP...or oral spice might give one more recall of trip details..to take back to baseline..

if one takes galantamine every day .. for weeks and months.. like elderly patiants with memory decline do to treat their allzimers... often going as high 40 or more mgs..per day].. when taken under a doctors care

the doctor slowly increases dosage to his patients because .. taken every day the body developes a tolerence to galantamine...

When i took galantamine...[for lucid dreaming]/.. i would only take 4mgs or 8 mgs...
[two or three times per week]..after 5 hours of sleep.. to boost dream vividness and recall...


https://youtu.be/_0g7eTYjmxA