I can’t seem to find much on this so I’d like to hear any of your speculations or direction if you’re better at research than me. My question is are our genetics a factor in the choice of psychedelics we should be looking for answers in? I did read a study on the effect of psychedelics on DNA and it made me wonder if we would be more genetically attuned to what our ancestors would have been pondering the universe with. So being of Irish decent should I turn more toward the concoctions of the kelts? I intend to experience as broadly as I can regardless but the concept got me curious.

I don't think it's quite as straight forward as you imagine. The presence of species in the immediate geographic area (or trading partners) and knowledge of them probably played a larger role in selection than preference based on genetics. I'm not sure if you're suggesting some sort of coevolution though.

Enzyme polymorphism and other differences in metabolism do change the response to many drugs. I'm sure there are other genetic factors that have been studied, and probably many more that have not.

Purely from a coevolution perspective. When thinking about how drastically humans altered the evolutionary course of whatever living resources were available and how much humans themselves adapted and evolved thanks to domesticated species, would we still have that genetic predisposition to better... handle or process or whatever... psychedelics our ancestors first implemented the idea of farming for? Just a curiosity that our genetic memory is more familiar to one door than to another if that makes sense.
In all honesty I don’t really feel anything is straightforward anymore but I am a curious one