I recently came down with a terrible cough and have been using promethazine (~12.5-25mg daily) for the past 3 days. I am also planning to take LSD this weekend and was wondering what, if any, interactions may take place between these two compounds. I am aware that promethazine is a weak antipsychotic with approximately 10% the potency of Chlorpheniramine and is an antagonist at the 5-HT2A, 5-HT2C, D2 and alpha-1 adrenergic receptors. Given this information, I would think that promethazine would mitigate and/or dull the effects of the acid, but I may be wrong. I was wondering if anyone has experience with taking these two compounds together and, if so, what were the effects? How did the addition of promethazine alter the effects of LSD?
If promethazine is not recommended for use with LSD, how long should it take for the antagonistic effects of promethazine to stop? I understand that promethazine has a half life of 16-19 hours but idk if the duration of its antagonistic effects are directly correlated with its half life.
As a side note, I was wondering if you have combined promethazine with any other psychedelics, and if so, what interactions did you notice? If my hunch is true, then promethazine's antipsychotic and antagonistic properties at serotonin and dopamine D2 receptors would mitigate the effects of psychedelics in general.
Thank you for your time and advice,
-Godsmacker
'"ALAS,"said the mouse, "the world is growing smaller every day. At the
beginning it was so big that I was afraid, I kept running and running, and I was glad
when at last I saw walls far away to the right and left, but these long walls have
narrowed so quickly that I am in the last chamber already, and there in the corner
stands the trap that I must run into." "You only need to change your direction," said
the cat, and ate it up.' --Franz Kafka