SWIM has had more luck taking them together.
Harmala alkaloids are short acting reversible MAO-A inhibiting compounds, also known as RIMAs. RIMAs don’t permanently bond to MAO-A enzymes. After some time, the MAO-A enzymes are able to remove themselves from the harmala alkaloids and become available again to destroy DMT. How long this takes likely differs from person to person.
SWIM has found that the most potent effects are had when the harmala alkaloids and the DMT are dissolved in the same cup of water (or juice, tea, coffee, etc.) and consumed at once, just like the shamans have been doing for hundreds of years. They do it this way because it’s the most effective method. SWIM normally dissolves the alkaloids in coffee. He finds that coffee is great at covering up bitter flavors.
Also, capsulating them is NOT a good idea. It doesn't work nearly as well that way.
I think the reason it works best when both are dissolved in water and taken at the same time is because this way MAO-A enzymes are overwhelmed with alkaloids. It’s a numbers game. If you take 200 mg of harmine, and it inhibits 100% of the MAO-A enzymes, and then wait 15 minutes, some of those MAO-A enzymes will have been freed from the harmine. As more time passes, more MAO-A enzymes are freed. The MAO-A enzymes are more attracted to harmine than to DMT, so when the two are put together along with the MAO-A enzymes, the MAO-A enzymes are attracted like magnets to the harmine, and the DMT pretty much passes through unhindered. But when you wait 15 minutes before taking the DMT, some of the MAO-A enzymes have freed themselves from the harmine, and so some of the DMT gets destroyed.
Anyway, that’s my understanding of it. The idea of waiting 15 minutes or so before taking the DMT just doesn’t make sense to me. By waiting, you’re giving your MAO-A enzymes time to free themselves from the harmine. What’s the point of that? The longer you wait, the more MAO-A enzymes become available again. Eventually if you wait long enough, all of them are freed again and the DMT will not work at all.
I think people believe that waiting 15 minutes ensures that more MAO-A enzymes are bound to the harmine. That just isn’t so. After 15 minutes, you can already feel the harmine. That means some has already passed through into the brain. More harmine in the brain means less harmine in the stomach to bind to the MAO-A enzymes! That’s my understanding of it. If you feel the harmine, the MAO-A inhibiting effects in the stomach are already diminishing. However, the DMT potentiating effects of harmine are just beginning.
There are two sides to this. Harmine acts as an MAOI in the stomach, but also later acts to potentiate the effects of DMT within the brain. Once the effects of the harmine are felt, it’s MAOI powers in the stomach are diminishing (because it’s passing into the brain), but it’s DMT potentiation effects are increasing. This might be why some people claim to get better effects when the DMT is taken when the harmine is felt, rather than at the same time. But for that, MORE harmine is needed. When taking the harmine and the DMT together, less harmine is needed. That’s what SWIM has found anyway.
You may remember me as 69Ron. I was suspended years ago for selling bunk products under false pretenses. I try to sneak back from time to time under different names, but unfortunately, the moderators of the DMT-Nexus are infinitely smarter than I am.
If you see me at the waterpark, please say hello. I'll be the delusional 50 something in the American flag Speedo, oiling up his monster guns while responding to imaginary requests for selfies from invisible teenage girls.