DMT-Nexus member
Posts: 58 Joined: 23-Jan-2014 Last visit: 31-Jan-2021 Location: usa
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Curious as to what one might expect in an experiment where prior to oral ingestion of 5meo and/or dmt, research subject already had selegeline/deprenyl in its system. Prior experiments with phenethalamine (pea) proved to be quite successful.
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DMT-Nexus member
Posts: 1843 Joined: 28-Jun-2012 Last visit: 20-Jul-2021
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Selegiline is a MAOI From: https://wiki.dmt-nexus.m...icity_and_general_safetyQuote:There is some concern regarding taking 5-MeO-DMT orally, specially with a MAOI. There has been at least one reported death (Sklerov, 2005; Callaway 2006 ), and some hospitalizations. This might be due to individual metabolic differences. Check this thread for more info. If you are consuming 5-MeO-DMT orally for the first time, specially with MAOIs, start VERY low and raise your dosage gradually. From: https://www.dmt-nexus.me...&m=153445#post153445picatris wrote:69ron wrote:
However, if 5-MeO-DMT is taken with an MAOI orally, much less is needed and the effects are much nicer. Itβs almost like DMT but more mental and less colorful, less visual.
I apologize 69ron but that is not a good advice! here's a better one: Do not use 5-MeO-DMT orally with a MAOI. 5-MeO-DMT is of known toxicity when used orally. Not everyone is affected in the same way, but there several cases ending up in Hospitals. You can find several reports in the scientific literature, where even some FATAL cases are documented. The problem is complex and different people are affected in different ways. Current research points to different allels of Cytochrome P450 2D6, that Demethylate 5-MeO-DMT into Bufotenin. This compound for several people can be highly toxic leading to extreme vasoconstriction even on low dosages of 2mg I have been researching 5-MeO-DMT for some time, specifically on that ROA. If someone really wants to explore that perillous path I would advise to start really low and measure the way up. Starting with possibly 100 mg harmaline and 1 mg 5-MeO, and very gradually, over several days, increase the dosage of 5-Meo-DMT. An important caveat is that, no matter what someone finds to be good for them with this compound, results should never be extended to other people for the reasons above. Also do check this: Hong-Wu Shen, Chao Wua, Xi-Ling Jiang and Ai-Ming Yu. Effects of monoamine oxidase inhibitor and cytochrome P450 2D6 status on 5-methoxy-N,N-dimethyltryptamine metabolism and pharmacokinetics. Biochemical Pharmacology Volume 80, Issue 1, 1 July 2010, Pages 122-128 A really state-of-the-art paper. + ---- + ---- + ---- + ---- + ---- + ---- + ---- + ---- DMT Nexus Research ---- + ---- + ---- + ---- + ---- + ---- + ---- + ---- +
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DMT-Nexus member
Posts: 4 Joined: 01-Mar-2011 Last visit: 08-Feb-2014
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Another thing to mention, is that selegiline is a MAO-B selective inhibitor. MAO-B is speficic to phenethylamimne substrates, and unlikely to have an effect on the metabolism of 5-meo-DMT (which is a Tryptamine, and broken down by MAO-A). That being said, it's unsafe to combine 5-meo-DMT with any form of MAOI, for reasons that the previous poster outlined. Stay safe!
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