So last night I took my first tab of some real LSD, I had tested it and it tested positive. However, now that its the next day, I feel like absolute crap. I feel almost like I was when I was battling depression a few years ago. I also feel somewhat sick and have a headache.

My question is, could this be from lack of serotonin? It was a great experience but if this is how it makes you feel the day after, I dont know if its completely worth it. Has anyone else experienced this?

Also, would taking some 5htp before going to sleep help replenish my serotonin levels, helping the feelings of depression and sickness?

As far as I know, LSD doesn't deplete serotonin levels like MDMA does. I usually feel fine the next day, so perhaps even though it tested positive for LSD, maybe it wasn't quite pure or maybe it was degraded and you had some kind of negative reaction. How was the trip itself? Positive or negative? I would eat some fruits and sleep on it (again).

The experience was a positive one. The tab was also completely tasteless so I do not think there was anything else on there. Plus it was a very tiny tab and very thin, not something that could absorb a larger amount of something else to be active. Eating some fruit sounds like a good idea, but I do not have any currently. I have been drinking a lot of orange juice though, if that counts.

Sometimes I've felt a bit cranky/out of it the next day after LSD, mushrooms and a few other psychs. Often I have powerful afterglows but sometimes I feel somewhat like what you describe. Sometimes I think it's just restless sleep and your brain being a bit tired. Get some sleep, relax and eat well and you will feel fine soon.

After a strong acid trip o feel similar empty and depleted. It kind of feels like a minor depression. Even after some strong shroom trips i had these effects.
It all vanishes after a day or two.

I experimented with Rue+shrooms around 20 times and this effect never occured. Always a strong afterglow. Even after taking this combo for 4 days in a row.
I do think it has something to do with the serotonin system.

I would advise against taking 5htp. Give your mind/body some time to harmonize itself. Eat some fruits and serotonin rich food, relax and sleep a lot. You'll be fine.

I dont feel as depressed today, but still feel sick. I woke up this morning to having to throw up a bunch, so I am starting to feel like it was not from the acid but that I was just coming down with something. Just bad timing I guess.