Been a lurker for a while here, and learned many invaluable things from the community.

In the near future SWIM will be ingesting San Pedro tea, shrooms, MDMA and DMT. The mescaline (18inches or so of cutting), the psilocybin, and the MDMA will be consumed simultaneously. The DMT (50mg) will be smoked in the form of changa at the peak of this experience.

To SWIM's knowledge this is not a combination that has been tried before. While that is most likely an understatement, SWIM has been unable to find information or a trip report for this mixture.

Does anyone out there have any advice pertaining to this experience? Especially health and safety wise (mental/physical)

Lastly, I apologize is this is the wrong section. It seemed like this might be considered "research".

Im sure it has been tried before..not by myself but someone will have! Mushrooms and DMT are very synergistic, as is DMT and LSD. I had a great experience on LSD DMT and ketamine once, truly in candyland
By the way mescaline and mdma are phenephylamines..

Safety wise Im no health professional but I would have on hand some valium if I were you..

That's quite a cocktail, I hope you are an experienced psychonaut...

Health and safety wise you want to go easy combining changa with mdma because of the possibility of serotonin syndrome, most people get away with it but the possibility does exist and should be taken into account; adding cactus to that mix could possibly potentiate this risk.

This is fairly unexplored territory, so proceed with caution.

Also, who knows how the other alkaloids in cacti are going to interact with the other substances.

VERY good point on the changa missed that bit. The risks will be exponentially greater when combining the others with MAOI unless its changa with an inert herb?
Also I advise not taking the mdma alongside the psilocybin you dont want to be coming down from mdma on the peak of a mushroom/mesc trip.

If it was me it would be san pedro first, then 4 hours later (maybe 5 or 6) shrooms then another 3 or 4 hrs mdma. With that ypu should get an intense synergy for a good 3 or 4 hours without any difficult comedowns during.. If non maoi changa then whenever you feel ready..if maoi changa I wouldnt know too many interactions going on..

Yeah defenitely beware of what you mix with Changa due to the MAOIs in it.
MAOIs from Changa will likely be very harmfull when mixed with MDMA.
Possibly lethal. Mixing MAOIs and Mescaline might also be. *

As for great psychedelic combinations:

-LSD + DMT + THC (LSDMTHC) is a fantastic combo. The best I ever tried. No words.
-Psilocybe Mushrooms + MDMA was very emotionally & philosophically enlightening.
-Paneolus Cyanescence(Hawaiian strain of shrooms) + LSD is very jolly and playfull.
-DMT + THC is a lovely combo. Cannabis instills a deep peacefullness that is very
welcome during the harder, colder & intenser experiences that can come on DMT.

I have yet to try Mescaline, but I may have my first Mescaline the next summer as I've
been growing a San pedro cactus for over 8 years or so. It's pretty tall, allthough the
top 3/4 of the cactus is quite thin. Though I think it should make for a decent trip.
But I won't be mixing it with anything as this will be my first ever Mescaline-cactus experience.


PS: Neither MDMA nor Mescaline are Tryptamines. Generally Tryptamines mix well together.
MDMA is an Amphetamine(Dangerous with MAOIs in general) and Mescaline is a Phenethylamine. * I've read some reports about some people OD-ing on Peyote.

Good idea on the benzos. Yeah, I realized that they're were tryptamines I just didn't know how to spell phenephylamines.

I forgot to mention that the "changa" really is just enhanced leaf, tobacco to be exact. So no MAOI that I know of.

As for Serotonin Syndrome, is this only a risk if there is an MAOI present? Or could this be a potential risk with the mescaline, psilocybin, and MDMA?

As for my psychonaut experience, I 'd say that two of my most powerful trips have been smoking deemsters at the peak of an LSD, 25i, DXM trip or plugging sherm. *Note* I didn't know it was 25i after the fact, and would stay clear away from that filth these days.

Doses will be 18ish inches of cuttings, 3.5g of gold caps, .3 of moll, 50mg of dimitri. If that helps evaluate risk factors.

Your dosages are a bit ridiculous to be honest. 18 inches of cactus alone is a heavy experience as is an 8th of cubensis. There really should be no need to break 200mg MDMA and that's pushing it. Any of these alone is enough to floor most people hard, let alone any combination, then adding breakthrough doses of DMT on top. What exactly are you trying to accomplish with such silly and irresponsible dosing?


I would strongly advise you examine your motivation, rethink your dosing, and if you should choose to pursue combinations you space them out and dose much more moderately.

300mg of molly.... lol

With that yes you are still at risk of serotonin syndrome and the combination could cause long term damage.
As has been said the doses are unneccessarily too high. Especially to get anything out of it other than being very high in at a risk. They will have much synergy anyway so no need to take so much you simply dont need to..

I appreciate the concern about the dosages, especially in synergy. However, 300mg of molly is about 300mg less than I usually take and I consider an eighth of mushrooms to be a minimal dose. And by minimal dose I mean a satisfactory psychedelic experience, not necessarily a threshold dose.

I feel that I must assure all of you that I am not doing this just for the sake of "pushing the boundaries"? I feel that is a useless pursuit after you've smoked DMT.

Lowering the dose for the mescaline and the mushroom, are just about out of the question. However,the general consensus seems that the mdma is frivolous. I would agree that at the considerable doses of everything else that the mdma roll with be nothing more than "noise" at best. Would this put you in the "safe" range? That being said with a grain of salt of course. Drug combinations are not something that I am unfamiliar, however I am much more experienced in the realm of Dissociatives. So for example, what would be the risk of serotonin syndrome for (mesc,mdma,shrooms,dmt) or (mesc,shrooms,dmt) vs (k,molly,shrooms) or (4meopcp,dxm,molly,25i,lsd,hydrocodone)?

As for the experience that I'm after with these "silly and irresponsible" doses, that would be a level 4 at least pre-DMT. Then a level 5 of course with the DMT. And eighter of shrooms puts me a 2, 3 at the absolute best.

http://www.youtube.com/watch?v=OLWfQxqiydc Explains the 5 levels of psychedelics.

http://www.erowid.org/experiences/exp.php?ID=70283


5 tabs LSD
10grams shrooms
1 gram extracted mescaline
about 100mg of 2c-b
1.5 grams MDMA
3 hits DMT (smoked, not sure of dosage, but I was fuckered up)
and lastly 6 bumps of K.

That's what is in that trip report, if anyone's interested. I hope it's obvious how the doses of the chemicals in question are all about 3 times, little less little more, than what I was planning. Not to mention the LSD, K, and 2c-B I wasn't even considering.

Be carefull and rsearch what your planning to ingest!
No shure I would want to try this kind of a mix?
You may get more of a positive experiance with one or two kinds of drugs?
But that many all at once! ?
Mixing that drugs may be dangerous!
Do Research first be safe!

Someone else being reckless and stupid is no excuse for you act foolishly. This kind of recklessness is against the attitude of this forum.

Man, that's some weak shit. I get that you can't understand why someone would want to do this, but that gives you no right to go and quote some policy on me, especially when you reference the "excessive use". The aforementioned doses are far from excessive. Excessive would be 36inches of cuttings, 7g of shrooms, and 500mg plus of moll. The fact you think that you consider 200mg of mdma "pushing it" and an eighth of shrooms a "heavy" dose shows either A)you clearly haven't "pushed it" as far as I have and am comfortable with, making you inexperienced and unable to answer my initial post or B) You're underestimating me as a psychonaut. To which that I'd like to remind that our post count on this forum is irrelevant to our experience as a psychonaut.

And to say that someone else acted foolishly is also an extremely judgmental statement, not exactly attitude friendly. Yes the levels of consumption in the trip report are absurd by almost any standard, but did you even read it? By the end of the report the author was speaking of major life epiphanies that he experienced on that trip. Excuse the hell out of me, but I thought that's what the experience was all about. I was under the impression that the Nexus was a community of minds who were able to see past the recreational value of these substances so that they may gain a new perspective and possibly, hopefully, learn something.

I came to this forum to see if there was any reason for legitimate concern. The general consensus seems to be that the mdma is overkill and adds an unnecessary risk factor for SS. I will follow this advice, unless I feel the need to drop the moll.

From a psychological standpoint, I couldn't be less concerned. I've gone to much deeper and darker places with sherm than any tryptamine (DMT excluded) would ever take me, nihilism realized to the fullest extent. I was only concerned with any physical contradictions that could have long lasting effects.

When someone is acting foolishly it is my job to call it out. This forum is based on harm reduction. Combining drugs at doses that push erowid's "strong" dose recommendations is extremely foolish behavior. You obviously do not fit this forums attitude, I recommend you find another forum, this behavior is not welcome here.

Personally I'd leave the molly out, keep it natural. Cacti are kind of speedy on their own. Depending on the potency of your cactus 18 inches could be a pretty strong dose. I'd probably eat the cactus wait awhile see how it goes and then eat the shrooms if I still felt like they were needed. I'd probably also have more than 50mg worth of changa on hand. That way if you want to go farther you can always just take a couple hits. I wouldn't really feel worried about serotonin syndrom from mixin those, but I would be if I was mixing molly with cacti.

If you do decide to mix everything together I'd definitely go light on the dosing to test the waters. You can always try more next time if you still feel like its a good idea.

"Some people may need specially higher doses due to personal metabolism"
Quoted from your own policy.

I have to say I am disappointed in you dreamer042. I was under the impression that this forum was intended for open minded discussion on DMT and related topics. Instead, I've been met with ridicule. Repeatedly have I been called a fool, yet it is the fool who can't conceive past his own perception. To you 200mg of mdma may be "strong", but for me I don't roll under 300mg. If you're astute enough, you'll notice that has a striking relevance to to "Some people may need specially higher doses due to personal metabolism". However, that being said, it is clear that there is no place in this forum for any sort of "challenge to authority". It seems that it even extends to disagreeing on dosage. Clearly the "elders", so to speak, of this forum do not see any need for any new exploration of the mind.

The LD50 of MDMA ranges from about 100-300 mg/kg in assorted rodents.[42] The single-dose LD50 in humans can only be guessed at, but may be on the order of 10-20 mg/kg (oral.) I feel that it should also be taken into consideration that the LD50 for someone of my size, 77 kilos, would be between 770mg and 1540mg, albeit it estimated. So in my initial dosages, I'd be consuming less than half of the low end of an LD50. That's hardly foolish, reckless, or irresponsible. It is also to take into consideration that the 200mg "strong" dose is the dose for someone who has never done molly before. Anyone with any sort of experience with mdma will tell you that it "loses its magic" after the first few times. AND, I did 500mg of the same moll last weekend.