I would assume that the simplest and most efficient way would be to finely shred the vine, and do 3x 1 hour boils, filter and reduce to a paste, leave till dry. This should be all the goodies extracted in the simplest way. I expect they would be in freebase form, and thus, smokeable.
"Eat your vegetables and do as you're told, or you won't be going to the funfair!"