I have a theory that something of this nature could work as a tryptamine potentiator by way of MAO dilution..

For a visual diagram, imagine this:
50 drug smuggling refugees are running for the border.
Border patrol has sufficient manpower, and they catch 25 of the smugglers before they make it through.

Now, imagine this scenario:
50 drug smuggling refugees hide among 200 starving immigrants, and charge for the border
Border patrol is overwhelmed, capturing 25 of the 250, perhaps as little as 5 of which are smugglers


Now replace 'drug smuggling refugee' with 'milligrams of active tryptamines'
Replace 'border patrol' with MAO
And replace 'starving immigrants' with 'mg of something MAO likes to react with'

And there you have it!

Better take tanks in the form of harmalas, they are way better in crossing the MAO border.


Kind regards,

The Traveler

Oh, of course! I was just thinking that taking one of these inert tryptamine-based substances, you could avoid having to space the MAOI/DMT dosing out.

doesn't quite work like that. see, those are not potentiators, they are precursors to 5ht and metabolites..which competitively bind the same receptors. it would actually act against what you want to achieve.

Is there something would react with MAO that wouldn't bind to those receptors or cause any negative side-effects?

MAO enzymes and the 5HT receptors are completely different proteins.
5HT receptors which act centrally are found in the raphe nuclei in the brain. MAO's which metabolize drugs are concentrated in the gut. Trav has the right idea, load up wif harmalaz

I realize this. I don't think you understand what Im trying to achieve. Please re-read my above post:

"I was just thinking that taking one of these inert tryptamine-based substances, you could avoid having to space the MAOI/DMT dosing out."

I realize Harmala will inhibit MAO production. But you still have to deal with the MAO that is in the gut prior to the Harmala taking effect. What Im looking for, is a substance that will mitigate MAO-A without interfering with the effects of the active tryptamines.

I don't think you understand that it does not work that way. MAO-A isn't exactly selective, neither are the 5HT receptors. you will get competitive inhibition.

and I don't know why you call the tryptamine precursors "inert", they are not. they react to form endogenous tryptamines, which compete for 5HT active binding sites.

you're arguing with a biochemist. I suggest what Trav suggested.. eat moar harmalaz

It doesn't necessarily have to be a tryptamine.

"A substance that will mitigate MAO-A without interfering with the effects of the active tryptamines."




Edit: Before Harmalas are suggested for the 4th time in this thread, please note that this substance would be used in conjunction with the Harmalas.

*facepalms*

you don't want hypertension, trust me. take harmalas alone.

indeed.

I'd advise against anything beyond RIMAs; what you probably want is a greater level of CYP450 inhibition, and that's no dice. sorry.

tryptophan and 5-HTP are not inert, they will form metabolites which will compete with dmt for binding receptor sites, so that theory goes out the window.

hmm..Piperine, perhaps?

What about aniracetam/piracetam?

piperine won't do much, but aniracetam is my fav.
now you're talkin'... aniracetam is reputed to be a 5HT2A modulator. IME, it potentiated psilocybin and dmt experiences.

IME, 4-AcO-DMT with Piracetam was an excellent combo. The only breakthrough trip that was achieved with that substance, irregardless of dosage, actually. Total fractal OEV immersion, points of total loss with consensus reality, etc. What I might imagine DMT to be like.

Plasmid, what you seem to want is to avoid the gut as much as possible and encourage the DMT to get into the blood and up to the brain as fast as possible.

To this effect, you might want to go with the sublingual ROA. Far less MAOI needed, and a relatively direct pathway to the blood brain barrier.

Plugging might be somewhere in the same league, and potentially longer acting.

And, then there's insufflation. Shorter acting by far, but much longer than vaporizing. And, that is without harmalas. Get some good beta carbolines in your snuff, and you can have your relatively instant effect with some duration. Search the forums for snorting or insufflation and you will find what you need. Try diluting your spice in a bit of vinegar, warm water, and a tiny dollop of coconut cream for an effective, no-burn solution I stumbled upon.

As for piperine, it does seem to increase the rate of absorption for certain things in the gut... also seems to get the blood pumping pretty good while thinning the blood somewhat. I imagine it is somewhat similar in effects to capascin (from chilis). Thus, I would strongly recommend against using it with any harmala. Hot spices are a no-no for the MAOI diet, and la dieta... they may be tolerated in small amounts while on RIMAs, but trust me, you don't want your ears burning, nose running, and heart racing for the duration of an ayahuasca journey. Really not.

A single sip of a wild coffee / molé (chocolate & chili) drink at the tail end of a journey made my dream teddy bear cry out to all the known gods of the various dimensions for mercy.

piperine inhibits CYP3A4, and has little affect on CYP2D6 (pinoline inhibits CYP2D6).

same house, different doors.

Interesting paper... dense read for sure.

One thing I got out of that was that piperine enhances the bioavailability of coenzyme Q10!

Frankly, chewing up a few peppercorns seems to enhance the bioavailability of a bunch of stuff.

Somehow the Indians seemed to grok this chemistry naturally as most curries are saturated with tumeric & pepper. Those curcuminoids seem to be rather noteworthy.