Hello

I have a question...

salvinorin alpha. 300mcg on a tab like lsd. Is this possible? and why has no one done this yet?


GREAT SCOTT!

Sure it's possible. Would be nice to administer sublingually and then puff on some DMT. I personally can't stand salvia so I'll never be doing this but people love it.

Just make sure to wear gloves as to not absorb the salvinorin...and be very careful about weighing and laying proper doses.

I'm a huge fan of salvia, I've only had it a few times but every time has been a life altering experience for me.
I hope to try this little experiment of mine at some stage in my plants life. And thanks for the heads up, though i would probably enjoy having salvinorin seeping through my skin.

Just beware, as you can easily overdose this way. Peace.

i enjoyed quid salvia but disliked the smoked stuff
tabs sound worthwhile, but absorbtion might be tricky
people seemed to experiment with liquid salvia a few years ago and reported inconsistent results

My friends who do this kind of work say salvia tinctures (ethanol) mixed with equal amounts (I believe this is the ratio please correct me if I'm wrong) WARM water and sublingually administer this. This apparently is a good way to do it, so I am not sure how tabs would work.

Maybe keep tabs for dosage reference, and then drop them in an alcohol warm water mixture and subling? Just an idea if the tab doesn't work good.

I assumed that tabs sat under the tongue? Would this not increase the absorption? and yes a dosage reference might be another way to do it but im not sure of a glass of paper water salvinorin a would go down a treat =P

So what is wrong with smoking it ? Its easy and very effective especially with enhanced salvia leafs.

I was reading somewhere that the absorption of salvinorin has a longer lasting effect. I like smoking it but i am after a longer duration. I also thought that this would be a safer way to mass distribute salvinorin A

Salvinorin A is not really active sublingually, it is best absorbed through the mucous membranes on the inside of your cheeks.

"Due to the digestive activity of the stomach and intestines and the solubility of the GI tract, the oral route is unsuitable for certain substances, such as salvinorin A"

From Wikipedia but no source.

When a chemical comes in contact with the mucous membrane beneath the tongue, or buccal mucosa, it diffuses through it.

Salvinorin A seems to be very resistant to absorption through the oral/buccal mucosa. I have about 2g of pure salvinorin A and have experimented with it in a number of ways: insufflation, oral, sublingual, oral and sublingual dissolved in acetone. None of these methods were effective. To be effective, massive quantities would have to be used, and even then I’m not sure they’d be effective. I used 10mg for each of the described trials, with no results.

Yet 750mcg vaporized in my GVG produced a very nice experience.

Some people don't like to smoke anything, due to the damaging effects of smoke on the lung tissues.

I’m not recommending vaporizing pure salvinorin A, but I can tell you from experience that there is essentially no smoke at all produced when an average-sized dose (1mg) is vaporized in a GVG.

Where did you get the idea that no one has done this yet? If you google "salvia blotter," there are plenty of relevant results.

I first remember reading about this at least five years ago. Among sphere's salvinorin extraction documents, there's one that details how to infuse salvinorin A onto cigarette papers. While these were intended to help standardize doses for smoking, it's not much of a leap to think of taking this stuff bucally. With a little googling, I found an old Shroomery thread that I remembered discussing this method.

Also, a minor quibble: There is no such thing as salvinorin alpha. The various salvinorin compounds are differentiated by the letters of the Latin alphabet, not the Greek alphabet. The only person who I've ever heard refer to it as "salvinorin alpha" was Terence McKenna, and every time I hear it I want to grind my teeth. I know it's probably not really that big of a deal, it's just a pet peeve of mine.




That's a gross oversimplification that completely ignores the complexity of membrane mechanics. There are entire companies who do nothing but develop novel formulations of drugs that will allow them to effectively diffuse across particular biological membranes. The two key challenges are addressing poor solubility and poor permeability... and unfortunately salvinorin A is both poorly soluble and poorly permeable.

As AlbertKLloyd mentioned, people often have inconsistent effects from ethanol tinctures. One of the reasons is that as the alcohol comes in contact with the saliva, the salvinorin A starts coming out of solution rapidly. As house mentioned, one of the common ways to overcome the burn of high-proof ethanol is to dilute it with hot water... this is easier on the mouth, but the effects become even less consistent because the solubility of salvinorin A in ethanol drops drastically when you get below 180 proof. Other solvents (acetone, DMSO) have been tried with similarly inconsistent effects. The reason that quidding leaves seems to be the most effective method seems to be because the other phytochemicals in the leaves help salvinorin A form an emulsion in saliva, which permeates the buccal membranes more effectively.

It's sort of a wonder that salvinorin A on a blotter would work at all... but according to redgreenvines (in the post linked above), it does work. It just takes a very large dose, somewhere around 10-20 mg. And you really have to "chew chew chew"... it seems that forming an emulsion is still critical. Just sticking it under your tongue and hoping for the best is probably going to lead to only mild effects.

There's no doubt some substantial work to be done in optimizing an effective means of administering pure salvinorin A... until there is a breakthrough in this area, your best bet is probably still quidding fresh leaf if you're looking for consistency.




You could as well ask that question of an ayahuasca drinker; the answer is the same. Vaporized doses of DMT and salvinorin A produce very abrupt and brief experiences. No doubt there is a lot of content in them, but it can be difficult to unpack meaningfully in such a short time. Longer experiences can be less jarring and allow more time to work deeply and extensively with the altered headspace of the experience.

I didn't think of that. :idea:

I was not aware that tabs were also known as blotters, will read into it. And thanks for the info entropymancer

not wrong per say
just know that there are some differences between traditional methods and smoking it
for example the visions and experiences are fairly distinct
few who smoke it report meeting the Goddess in her garden

Reading through this thread makes me inclined to try quidding salvia finally. I've always just smoked extracts. Unfortunately I don't know of any local place that has intact salvia leaves, so I guess I'll have to get on doing my homework The idea of quidding it was always kind of scary for me anyway because I wouldn't want to lower myself into a state of madness like that, but after reading the ayahuasca/vaped DMT comparison, it makes me a little more secure in wanting to try it.