CO2 levels in the blood will rise when running a marathon as a product of cellular metabolic processes (called cellular respiration); it forms H2CO3 (carbonic acid) in the blood itself by becoming soluble in the plasma part of the blood.As it dissociates into H+ and HCO3-, the H+ ions have a direct effect on the central chemoreceptors in the brainstem (and some peripheral chemoreceptors too) to stimulate the process of ventilation ie breathing thereby eliminating the CO2 which has built up in the blood, via the lungs.
Thats a brief description of what occurs.The level of CO2 in the blood also has an effect on the release of oxygen by its carrier, hemoglobin.As CO2 is acidic when rendered into a solution the kidney also is affected as the kidney is actually most responsible for maintaing the correct pH of the circulating blood.
I am paranoid of my brain. It thinks all the time, even when I'm asleep. My thoughts assail me. Murderous lechers they are. Thought is the assassin of thought. Like a man stabbing himself with one hand while the other hand tries to stop the blade. Like an explosion that destroys the detonator. I am paranoid of my brain. It makes me unsettled and ill at ease. Makes me chase my tail, freezes my eyes and shuts me down. Watches me. Eats my head. It destroys me.