I've heard that mescaline crystal, natural product from fresh cactus, and natural product from dry cactus all have different effects. Have those of you that are experienced with various methods of administration found these differences to be significant or minor?

I've also read that both drying and extracting weaken the experience (assuming it is derived from the same amount of plant material). It seems that this would be due to alkaloids being lost in the process. Have you found this to be a noticeable issue either?

oo the great mysteries of life...

some cacti have synergetic alkaloids that "flavor" the mescaline experienc/
very little is known about them, ie dioes heat or extraction reduce them(subjectively yes it may) we also dont know which of them are extracted using the methods that are around these days.

mescaline itself willNOT be damaged by heat or extraction, its one tough alkaloid

one of my favorite methods is to eat a medium amount of crystal mescaline, then eat peto until i cant eat any more.
the peyo alks add to the experience for sure

maybe this is of interest:

https://www.dmt-nexus.me...aspx?g=posts&t=12943

Perfect, don't know how I missed it. Thanks.