Since I have no experience I can only tell you what I read from the book "the Spirit Module".
The doctor had decided to give one of the subjects .2mg per kg, and it seemed to have little effect. To his regret he tripled the dosage based on the subject's request to .6mg per kg. The subject went out of control. The subject was vomiting, hiding under the covers in the fetal position, trying to escape the bed, and they had to physically restrain him. He eventually came back down, and his first words were "On second thought...maybe somewhere between .2 and .6. So they landed on .4mg per kg, which is what he should have done to begin with. He learned from another doctor later that he also tried giving people too much and found that > .4 mg per kg the subjects didn't do well, often became ill, and forgot most of everything they experienced.
So if for instance you are a 91kg man (200 lbs US) that would be 91 * .4 = 36(ish) mg
Anyways, ultimately I don't know, but per the experiments from that book, that seemed to be where they landed on break-through dosages. Also keep in mind they were injecting it.
Hope that helps.
"You are what you seek" - Remi
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