So through my experiences with taking dmt with my close group of travelers, I have begun to wonder if we should be administering doses based on weight of the individual.
I am a rather large individual. I stand 6foot 5inches, and weigh in at 313lbs or 141.9kgs for the metric world. I have a fair bit of flab now, but was once athletically built. That just means I'm not a soft in the middle as I may appear at first... with all that said, one of my traveling partners only weighs in at 155lb or 70.3kgs, he doesn't appear to have an ounce of fat on him. Nobody in our traveling circle is on any kind of pharmaceutical drugs.
Last night we went on a trip in which we all invested 30mg, with the exception of one person who only took 10mg. She weighs in at around the same as my 70.3kg friend. Her 10mg, gave her a mild breakthrough, even though she wasn't trying to go that far. My male 70kg friend had a full breakthrough, that had lasting visuals for over 45min. My trip lasted for about 14 min, my longest yet. And I had a full on conversation with a female entity that I have encountered many times.

So doing some quick math, my dose is roughly .2mg/kg while my friend is getting over .4mg/kg...
Does that mean if I took 60mg I would see visuals for 45min? Still trying to feel my way through this wild chemical

I feel vaping technique and how long it took to get the dose in is more important for vaping/smoking.

For sure eat harmalas (or smoke) before vaping spice to extend the trip and maybe even slow the come up a bit.

I can see natural MAO activity or something to do with metabolism having a rule to play. I feel we are all vaping the spice equally well. Receiving the full 30mg with 2 inhales.
I just feel like we're aren't taking body weight into account. Any other chemical administered by a physician would be dosed based on an individuals weight. The LD50 of dmt is measured in mg/kg at 90-110mg/kg, so why wouldn't the threshold, effective, and breakthrough doses be measured the same way?

You could incrementally increase until reaching that dose to find out.

You're not wrong in considering that weight plays a role in effects. But how big a role? And how much weight does this role carry in comparison to other variables with this particular molecule? I think that with most psychedelics, weight plays more of a role in oral ROA versus inhaled, IM, or IV.



However, DMT is a weird one. With this molecule, which very much unlike most pharmeceuticals (I think we can all agree) it just doesn't seem to behave that way and is very much attuned to other factors with regards to depth of experience. While it was shown that certain aspects of the experience increased as the dose increased for participants in the Imperial College of London extended state study, I don't recall it being completely uniform for all aspects of subjective experience assessed; it was more generalized (granted it wasn't a large test group size).

Now, I'm in the Shulgin camp regarding the LD50 as a poor standard in this first place. However, in this context, it doesn't stipulate anything to degree of phenomenological effect in a given subjective experience. It simply stipulates the dose required to kill 50% of rats (and then assumed to be the same roughly for humans), but that doesn't mean much in terms of overall effect across the board.

As an example. I've vaped 10mg more times than I can count. I double check my doses. There have been times that I don't get much to times where I've "broken through" on that amount. It's a crap shoot everytime.

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