After researching that yopo is active via smoking, I'm wondering if anyone tried it with an emesh?
Just to see what temperatures and dosage are good

Smoking the seeds is not recommended because you can combust harmful toxins and it might be difficult to get a good enough dosage in to feel much. E-mesh will help mitigate this but probably not to any extent worthwhile. I recommend extracting pure bufo from the seeds. I would imagine pure bufo would work nicely with e-mesh.

See the wiki for freebase bufotenine vaporization temperatures.