Thank you again for looking into it.

They did mention this about the iso-form selectivity of RIMA, it seems dose dependent:
I'm pretty sure that our session doses can be considered in the last part of that sentence. So this is still confusing.
What is left out of the equation (I dunno why) is that RIMA's on their own lower blood pressure, while the augmented tyramines will rise blood pressure. I can only imagine they counter each other out somehow? Yet I would naively expect that the excerpt above is result of clinical measurements voiding any mind driven hypothesis.


I'm with you on this one, I've also used L-dopa (mucuna extract) as a literal part of pharmahuasca dosing with very good results. I got a storm of critics (on another forum) for even trying and posting that, but I was veeeery carefully with my L-dopa doses used.




Obviously the body will come into a new equilibrium and is going to react differently. One can't however tune general advise to such a point because the percentage of people going that route is marginally small I'm afraid. I believe absolutely you're right but there is a relative aspect to it. But you make for a good motivator to acquaint ourself for the better



There was a precursor, people are just as confused as the information they find.


I agree with "just fine" and that comes down to my imho conclusion so far about the term RISK:

* is there risk of needing assistance, a doctor, ER, fatality? We can say fairly confident NO. Unless you're the odd anomaly that makes up for the exception ( = disclaimer).

* is there potential risk of affecting the nature of the session? Here I say YES. Then we must speak of degrees of affection that probably ranges from near-to-not noticeable to a very uncomfortable skewed session in extremis, all according to the level of harmala acquaintance (your point), tyramine level of used food, personal sensitivity, med history, and whatnot...

Imagine a low degree of affection. I'm quite sure any person is unable to discern these particular low induced effects in the heat of being tossed around in the trip, and quite understandable actually.
Think of it like: in an opera it's hard to discern if a one violin has a string off it's perfect tuning. No problem, no drama, 99% will not even know, but it could have been better without people realizing.

That's how I connect the dots for the time being.

I've not seen a single study or paper indicating issues with reversible MAO inhibition and tyramine or even catacholamine like phenethylamines.

In fact the few papers I have seen about hypertensive crisis and serotonin syndrome specifically state that the risk is with irreversible inhibition of MAO.

I've taken caapi leaf and bark and esphand and have ingested plenty of tryamine rich food and various PEAs and haven't ever observed any negative symptoms.

I've combined caapi leaf and yopo too, but I admit I don't take large doses of yopo.

@Jees - I'm not sure, but seeing as how their resources are from '88, and there's been newer studies done on Harmalas, and Moclobemide, and RIMA's in general, the newer evidence seems to indicate that there is either no Tyramine risk or the risk is very very low, especially with Moclobemide but RIMA's in general. The fact that the gut's MAO-A inhibition is reversible (short lasting, up to about 2 hours ime) and it's selectivity for MAO-A and non-inhibition of MAO-B, there should very well be no Tyramine interactions. Harmalas do inhibit CYP2D6, which also metabolizes Tyramine, but again so does Moclobemide apparently and Moclobemide hasn't shown any Tyramine interactions that would be of cause for concern, but Tyramine is metabolized out by quite a few enzymes apparently, so i don't imagine inhibiting MAO-A and CYP2D6 would be enough to cause much, if any, issue, it could perhaps raise Tyramine levels slightly, but the general consensus seems to be that RIMA's do not pose the same risks as MAOI's, drug to drug interaction wise yeah need to be careful about that, but dietarily, not really, i'm willing to bet it's just side-effects of the Harmalas rather than anything dietarily, as is clearly obvious ime when the Harmalas are cleaned up by building up the reverse tolerance. MAO-A inhibition itself can apparently cause transient side-effects for the first week or two of regular consumption.

@0_o - Same here. Much of the recent evidence seems to show that RIMA's have no real dietary concerns.

Wow, this conversation went beyond the boundaries of my understanding long ago... I'm thinking... why don't you guys work in one "blog post" about it, in which you would writte in dynamic level of complexity ( start so everyone understand the real risks, and add complexity and details as the entry develops for those who can understand and are eager to know) with the real implications between MAOI and human health, my previous search was so misleading, but this thread has clarified all the questions I had and will ever have about it, then we post this here in DMT nexus and copy pasted around the web, in as many blogs etc with links to the nexus post to make that entry one among the first on Google search, might help a lot of people I think...

How many seeds? Was the experience similar to the Yopo snuff or it differs in any way? Was it orally?

If so how did you prepared it?